Synthesis, spectroscopic characterization and pharmacological evaluation of novel copper mediated antibiotics
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 2
Abstract
A series of novel copper mediated antibiotics were prepared from N4 – substituted having structure [Cu (L)2] Cl2. All compounds were characterized by various physico -chemical techniques like melting point, TLC, elemental analysis, IR, H1-NMR, LC-MS, UV-Visible spectroscopy. The magnetic moments and electronic spectral studies suggested distorted octahedral geometry for all the compounds. The monoanionic orthophenylene diammine ligands were in a bidentated mode, binding through azomethine nitrogen atoms of substituted bis carbohydrazones. The synthesized compounds were screened for their in vitro antibacterial activity using disc diffusion method against two strains of gram negative and gram positive bacteria. Streptomycin antibiotic was used as positive control. All compounds showed significant antibacterial activity in the range of 1-10 mg/ml. Invitro antioxidant activity of the all copper compounds was screened by using the DPPH scavenging assay by using ascorbic acid as a positive control. All compounds exhibited potent antioxidant activity in the range 80-90%. . The Invitro-cytotoxic activity of compounds against breast cancer cell lines MCF-7 was evaluated for all the above compounds. All compounds were found to be highly active against the studied cell line; presenting the similar values of IC50 around 10 mmol/L. These compounds would be evaluated further for their possible DNA binding, cleavage, antifungal and anti-diabetic properties.
Authors and Affiliations
Richa Kothari
Keywords
Related Articles
- EP ID EP312295
- DOI -
- Views 58
- Downloads 0
Antioxidant and Antibacterial compounds from the leaves of Psidium guajava
Psidium guajava Linn., family Myrtaceae, commonly known as guava, is an important food crop and medicinal plant in tropical and subtropical countries. Previous studies reported major contribution of the ethyl acetate fra...
Evaluation of Hypoglycemic Effect of Two flavonoidic Compounds Isolated from Iraqi Phoenix dactylifera (Gintar) Leaflets in Alloxan-Induced Diabetic Rabbits
Diabetes Mellitus (DM) is a chronic metabolic disorder disease resulting from lack in action of insulin hormone. Thin Layer Chromatography (TLC) results showed presence of two flavonoidic spots from phoenix dactylifera(G...
Fenugreek [Trigonella foenum-graecum] linn- a reducer of glucose and lipid profile in diabetic subjects
Back ground: Recently use of herbal medicines, have been considered as an alternative for therapeutic usage. Fenugreek (Trigonella foenum graecum Linn), used as traditional medicine and natural additive food, has been sh...
Dystonia: A systemic review
Dystonia is a development issue in which muscles contract automatically, causing dull or bending developments. The condition can influence one a player in your body (focal dystonia), at least two adjoining parts(segmenta...
Preferred learning styles of second year medical students
Medical students differ in intelligence, personality, aptitudes and rate of learning. By identifying and adopting their preferred learning styles, the process of learning will be enhanced which further helps in achieving...