Comparative Study of Anticonvulsant Property among Different Fluoro Substituted Synthesized Benzothiazole Derivatives
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 6
Abstract
Objective: The present study is to evaluate antiepileptic activity of some fluoro benzothiazolo oxadiazolo quinazoline and sulfonamido quinazoline derivatives. Background of the Study: Epilepsy is a chronic disorder of the brain, characterized by the periodic and unpredictable occurrence of seizures. Epilepsies affect around 1–2% of the world population including the fact that the convulsions of approximately 25% of epileptics are inadequately controlled by medication. Materials and Methods: Albino mice (weighing 20-25g) of either sex were used in this study. MES seizures were induced in mice by delivering electroshock of 60ma for 0.2 seconds by means of an electro- convulsiometer transauricularly through a pair of ear clip electrodes. Both test animals and standard group received diazepam (5mg/kg) p.o strychnine nitrate (1 mg/kg) was administered. Results and Discussion: MES induced convulsion the mentioned dose was administered one hour prior to MES elicitation. It was observed that all SSBDs except ap-7, bz-10 and s-5 shown significant anticonvulsant effect. The results are compiled in the Table 1 and graphically depicted in Figs 1 and 2 respectively. Conclusion: The present investigation revealed that the SSBDS ap-3, ap-6 and bz-9 were shown significant anticonvulsant activity against both MES and strychnine induced models.
Authors and Affiliations
I. Shanmukha, A. M. Madhusudhana, E. Jayachandran, M. Vijay Kumar, B. Prakash
Keywords
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- EP ID EP344941
- DOI 10.9734/BJPR/2014/6876
- Views 95
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