Effect of Ascorbic Acid on Co-trimoxazole Induced Hyperbilirubinemia in Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 6, Issue 4
Abstract
Aims: To evaluate the effect of ascorbic acid on co-trimoxazole induced hyperbilirubinemia. Place and Duration of Study: Laboratory of Raghavendra Institute of Pharmaceutical Education & Research (RIPER), between July 8, 2014 to July 23, 2014. Methodology: Rats were divided into three groups of six each, Control group were treated with vehicle, Negative control group were treated with co-trimoxazole (36 mg/kg of body weight) and Test group were treated with ascorbic acid (500 mg/kg) and co-trimoxazole (36 mg/kg of body weight). All the groups were treated once daily for a period of 15 days. After one hour of oral administration, blood were collected by retro-orbital method on 1st, 5th, 10th, and 15th days and bilirubin levels were estimated by using semi-auto analyser. Results: Animals treated with co-trimoxazole have none significantly increased on bilirubin level at day 1st but bilirubin levels were significantly increased on 5th and 15th days of test (P<.001) when compared to normal group. However, Animals treated with ascorbic acid + co-trimoxazole have none significantly decreased on bilirubin level on day 1st but from day 5th today 15th bilirubin levels were significantly decreased (P<.001), when compared to negative control group. Conclusion: On administration of ascorbic acid to rats, the hyperbilirubinemia which was induced by Co-trimoxazole decreases. So, the combination therapy of co-trimoxazole and ascorbic acid has the beneficial effect over hyperbilirubinemia caused by co-trimoxazole.
Authors and Affiliations
Nabin Wagle, Hari Prasad Sapkota, Nim Bahadur Dangi, B. Sreedhar Naik, Y. Balakrishna, S. Nagarjuna, Y. Padmanabha Reddy
Keywords
Related Articles
- EP ID EP344353
- DOI 10.9734/BJPR/2015/14719
- Views 88
- Downloads 0
Determination of the Infective Dose of Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC 27853) When Injected Intraperitoneally in Sprague Dawley Rats
Objective: To determine the infective dose of Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC 27853) in Sprague Dawley rats, when the inoculum is injected via the intraperitoneal route. Design and Met...
Pharmaceutical Quality Analysis of Ceftriaxone Sodium Brands Marketed in Southern Nigeria
One of the paramount controversies between Physicians and Pharmacists is the issue of generic substitution. Prescribers are compelled to choose from such a large range of brands. The objective of this study was to compar...
A Prospective Study for “Developing School Based Model for Mainstreaming Rational Use of Medicine”
Background and Objectives: For mainstreaming rational use of medicines (RUM), consumer education is a must. It was felt that a school based model, developed to empower teachers regarding RUM using a modular programme, ca...
Ethanol Extracts of Terminalia ivorensis (Chev A.) Stem Bark Attenuates the Positive, Negative and Cognitive Symptoms of Psychosis in Experimental Animal Models
Aims: This study was undertaken to evaluate the antipsychotic property of the ethanol extract of T. ivorensis (EETI) stem bark in mice Study Design: The study used experimental animal models predictive of human psych...
In vitro Antibacterial Activity of Maclura tinctoria and Azadirachta indica against Streptococcus mutans and Porphyromonas gingivalis
Introduction: Azadirachta indica and Maclura tinctoria are two plants that have been reported with some ability to inhibit the growth of different types of bacteria so the aim of this project was to evaluate the in vitro...