Comparative Study of Artherogenic Effects of Common Nigerian Edible Oils in Male Rabbits
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 20, Issue 7
Abstract
Aims: To compare the atherogenicity of edible oils namely, palm, groundnut and egusi melon oils in male rabbits by determining their lipid profile and presence of atherosclerosis in their aortas. Methodology: Twenty-five 8 weeks old male rabbits divided into five groups were used. Group A served as control and was fed on normal chow. The remaining four groups were fed on normal chow fortified with cholesterol, palm oil, groundnut oil or egusi melon oil respectively. At the end of 12-weeks, animals were fasted overnight and their blood samples were assayed for total cholesterol (TC), high- density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels. Atherosclerotic lesions of the vascular walls were classified according to American Heart Association (AHA) classification. Results: The TC was significantly lower in egusi melon oil group (63 ± 19 mg/dl) than in controls (103 ± 8.8 mg/dl) with p-value < 0.001. They also had the lowest non-HDL-C (38 ± 19 mg/dl), significantly lower than that of controls (87 ± 9.7 mg/dl), p-value< 0.001. The palm oil fed rabbits had the highest plasma HDL-C (33 ± 2.0 mg/dl) that was significantly higher than that of controls (17 ± 0.55 mg/dl) but not significantly different for animals fed on groundnut oil (27 ± 5.1 mg/dl) or egusi melon oil (25 ± 2.3 mg/dl). Rabbits fed on egusi melon oil had the lowest AI (1.5 ± 0.79). Rabbits fed on palm oil had lower tunica intima (TI)/tunica media (TM) ratio than other groups p <0.001. Atherosclerotic changes in keeping with AHA type II lesions were found in aorta of rabbits on groundnut oil and egusi melon oil. Conclusion: Egusi melon oil produced better plasma cholesterol lowering effect but still produced atherosclerotic lesion. No lesion was observed with palm oil supplemented diet possibly because the group had the highest level of HDL-C that is considered to reduce cardiovascular risk. Further evaluation of the test oils is needed to identify factors responsible for their beneficial and atherogenic effects.
Authors and Affiliations
Olulola Olutoyin Oladapo, Modupeola Oluwabunmi Bolaji, Omotola Abdul-Malik
Keywords
Related Articles
- EP ID EP311467
- DOI 10.9734/BJMMR/2017/32060
- Views 70
- Downloads 0
The Relation between the Clinical Presentation of Acute Carbon Monoxide Toxicity and Carboxy-hemoglobin Level
Background and Objective: The symptoms of carbon monoxide (CO) poisoning are nonspecific; symptoms can mimic those of other common diseases such as nonspecific viral illness, flu- like syndrome and hypertensive attack. E...
The Effect of Bariatric Surgery on Bone Health
The prevalence of obesity, with its associated co-morbidities, is on the rise, and bariatric surgery is proving to be an effective means of allowing sustained weight loss as compared to alternative strategies. Follow up...
Cone Beam Computed Tomography for Exploring Morphology of Mandibular First Molar
Aims: The root canals have complex morphology and vary widely among individuals variations. The objective of this research was to analyse the morphology of root canals and existence of extra canals in mandibular first mo...
Dietary Patterns and Weight Loss in New-onset Type 2 Diabetes Mellitus: A Sub-analysis of the St Carlos Study: A 3-year, Randomized, Clinic-based, Interventional Study
Objective: To assess lifestyle patterns associated with weight loss in newly-diagnosed type 2 diabetic patients (T2DM) in the St Carlos Study. Design: A 3-year, randomized, interventional study with three parallel groups...
Ex vivo Analysis of Three Electronic Apex Locators Accuracy with Different Settings
Aims: The correct determination of a root canal length is a fundamental step for an adequate chemical-mechanical preparation and consequently, for a successful endodontic treatment. Electronic apex locators (EAL) were de...