Comparative Study of Efficacy and Safety of Azilsartan with Telmisartan in Hypertensive Patients
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 5
Abstract
Introduction: Hypertension is defined as either a sustained systolic blood pressure of greater than 140 mm Hg or a sustained diastolic blood pressure of greater than 90 mm Hg. Chronic hypertension can lead to heart disease and stroke, the top two causes of death in the world. Angiotensin receptor blockers are more selective blockers of angiotensin and have the potential for complete inhibition of angiotensin than ACE inhibitors. The aim of this study was to compare safety and efficacy of newer ARB Azilsartan with Telmisartan. Material and methods: This prospective study was carried out in patients attending the Department of Medicine, RVMIMS. Patients with newly diagnosed with stage I-II essential hypertension of either sex within the age group of 18–65 years with blood pressure of ≥140/90 mmHg were included in the study. Severe hypertension >180/110 mm of Hg, hypersensitivity to ARBs, secondary hypertension with any other etiology, pregnant women, history of Drug/ Alcohol abuse, cardiac arrhythmias were excluded. Patients who gave consent for the study were divided into 2 random groups 1 and 2 – the first received azilsartan and the second received telmisartan. Point of control was defined as blood pressure<140/90 mm of Hg after initiation of therapy. Results: 204 patients were randomized into two groups. Out of 104 patients included in group 1 who received azilsartan, 3 were lost for follow up. Out of 100 patients included in group 2 who received telmisartan, 12 were lost for follow up. There was no significant difference between the two drugs in both mean systolic and diastolic blood pressure at 6hrs, 15 days, 1 month and 3 months. Mean diastolic blood pressure at 24 hrs was reduced more with telmisartan compared to azilsartan which is significant. Hypotension related adverse effects occurred in 3% of the patients in azilsartan group while it occurred in 8% of them in telmisartan group. Conclusion: Azilsartan is an effective blood pressure lowering drug with its safety and efficacy comparable to that of telmisartan.
Authors and Affiliations
Sashidhar Reddy, Mary Rohini, Prasanna . , Rakesh . , Lokesh .
Keywords
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