Comparative study of efficacy of Tramadol versus Pethidine in post-operative pain control following laparoscopic abdominal surgeries
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 4
Abstract
Abstract: Post-operative pains following surgical procedures are very important aspect for overall success of treatment and well-being of patients. Surgeons and anesthetists have used various drugs to control postoperative pain relief. We in the present study tried to evaluate the efficacy of Tramadol for postoperative pain control compared with Pethidine in patients undergoing various laparoscopic abdominal surgeries. This study was performed in CAIMS Hospital Karimnagar. 60 patients divided into two groups (n=30) The patients were undergoing various abdominal surgical procedures like Laparoscopic Cholecystectomy, Hysterectomy and Appendectomy, Group I receiving Tramadol and Group II receiving Pethidine. Fifteen minutes before the end of surgery, patients were randomly given Tramadol HCl IV 1.0 mg/Kg loading dose followed by 50mgIV every 4 -6 hours up to total max daily dose of 400mg. The second group of patients received PethidineHCl IV 1.0mg/kg loading dose followed by 25mg IV every 4-6 hours not exceeding 400mg/day. The cumulative analgesic consumption over 24 hours was monitored and post-operative pain by Visual Analogue Scale (VAS) was compared between the two groups. The Mean age of Group I was 35.5 and Group II was 39.5. All the patients selected for the study belonged to ASA class I or II categories. The VAS scores in Group I were 5.5 ± 1.0 and Group II were 4.5 ± 1.0 the p values were significant. The number of patients requiring rescue analgesia (VAS > 6) with IV fentanyl 1µg/Kg in Group I was 11 and in Group II it was 4 patients. The cumulative analgesic consumption in Group I at the end of 12 hours were 250 ± 50 mg and Group II was 150 ± 25 mg and at the end of 24 hours Group I values were 300 ± 50 mg and Group II was 200 ± 25 mg. The efficacy of tramadol for management of post-operative pain in equianalgesic doses is slightly inferior compared to pethidine as suggested by the pain scores, cumulative analgesic requirements and rescue analgesic required, however unlike other opioids, tramadol has no respiratory depression effects and does not affect the cardiovascular functions adversely. It may be used as a safe alternative analgesic in cases where opioids otherwise contraindicated. Keywords:Tramadol, Pethidine, Postoperative pain
Authors and Affiliations
Bhimireddy Venkatareddy, Padma Polagani
Keywords
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