Comparative Study of Efficacy of Two Different Doses of Epidural Dexmedetomidine ( 0.6µg/kg and 1µg/kg) with 0.75% Ropivacaine for Inguinal Hernioplasty
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Epidural anaesthesia is one of the most common regional anaesthetic technique used for lower abdominal and lower limb surgeries. Various adjuvant are being used with ropivacaine for prolongation of intra operative and postoperative analgesia in epidural block. Dexmedetomidine, the highly selective α2 adrenergic agonist is a new neuraxial adjuvant gaining popularity.Dexmedetomidine has dose dependent action when used intrathecally and not much studies have been conductedto determine the efficacy of different doses of dexmedetomidine in epidural anaesthesia.So in our study we selected two different doses of dexmedetomidine(1 and 0.6µg/kg)to determine the efficacy with ropivacaine.Aim of the study was to evaluatethe efficacyof two different doses of dexmedetomidine(0.6µg/kg and 1µg/kg)as an adjuvant to to ropivacaine 0.75% in epidural anaesthesia for elective inguinal hernioplasty surgeries. Materials and methods: One Hundred Patients scheduled for elective inguinal hernioplasty under epidural anesthesia participated in this study. They were assigned into two groups: Group A (n = 50), 15ml of 0.75% ropivacaine plus 0.6µg/kg Dexmedetomidine given and in Group B (n = 50), 15ml of 0.75% ropivacaine plus 1 µg/kg of Dexmedetomidine given. The Following variables were studied: onset of sensory and motor block, duration of sensory and motor block, maximal dermatomal level of analgesia. Results: Group B had rapid onset of sensory and motor blockade (p<0.05), prolonged duration of sensory, motor block (p<0.05), and determine more intense motor block (p<0.05), greater sedation scores compared group A.Side effects like hypotension and bradycardia were observed more with group B but it was not stastically significant.There was no difference in the maximal dermatomal level of analgesia. Conclusion: Epidural Dexmedetomidine at 1 µg/kg as an adjuvant to 0.75% Ropivacaine is associated with prolonged sensory and motor block, hemodynamic stability, more intense motor block and greater sedation scores when compared to dexmedetomidine 0.6 µg/kg with Ropivacaine.
Authors and Affiliations
Swarna Gowri S, Sreeharsha Sirigeri
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