Comparative study of fetomaternal outcome following induction of labour using sublingual versus vaginal misoprostol
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 2
Abstract
The objective of this study was to compare the efficacy and safety of sublingual with vaginal misoprostol in induction of labour. This was a tertiary hospital based interventional comparative prospective study comprising total 200 pregnant women. In Group 1, 100 women received 25 μg sublingual misoprostol and in Group 2, 100 women were given same dose intravaginally. Misoprostol in both group was repeated every 4 hourly up to maximum 3 doses. Outcome in respect of percentage of vaginal delivery, induction- delivery interval and feto-maternal parameters were observed. Statistical analysis was done applying Student ‘t’ test, z test and Chi Square test. In 70% women delivered vaginally in sublingual and 76% women in vaginal group (p-value= 0.33). Induction delivery time was comparable in two groups (11.36 ± 3.5 hours versus 10.5 ± 3 hours respectively, p = 0.11). In the sublingual group, uterine hyperstimulation syndrome was observed in two cases and in one case of group 2 which occur after the second dose of misoprostol. APGAR score at 1 and 5 min was comparable in two groups (7.67 ± 1.01 versus 7.69 ± 1.02, p = 0.89 and 9.14 ± 0.9 Vs 9.02 ± 1.14, p - 0.41 respectively). As sublingual misoprostol is equally effective and safe but more acceptable to patient and has better ease of use in comparison to vaginal route, it may be concluded that the sublingual application is a better alternative to vaginal route.
Authors and Affiliations
Hasibul Hasan Shirazee, Bhawana Goel, Mandira Dasgupta, Anuradha Phadikar, Anjum Naz, Sudip Kumar Saha
Keywords
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