Comparative Study of Intravenous Ondansetron and Dexamethasone for Amelioration of Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 2
Abstract
Background: Postoperative nausea and vomiting (PONV) is considered most unpleasant experience by the patients in postoperative period. In particular, following laparoscopic procedures the incidence of PONV is very high. The present study is aimed to assess the magnitude of PONV after laparoscopic cholecystectomy and to compare the relative effectiveness of two drug Ondansetr Dexamethasone Subjects and Methods: Ninety adult patient of either sex in the age group of 20 to 50 years of ASA I or II were randomly divided into one of the two groups of forty-five each. Group A patients received 4 mg of ondansetron intravenously towards end of surgery. Group B patients received 8 mg of Dexamethasone injection at the time of induction of anaesthesia. Postoperatively, the patients were assessed for episodes of nausea, vomiting and need for rescue antiemetic at intervals of 0–1, 1-2, 2-4, 4-8, 8-12, 12-24 hours. Results: The incidence of PONV up to 4 hours after surgery was 6 and 9 in Group A and Group B respectively (p>0.05). Thereafter during 4 to 12 hours after surgery, the incidence of PONV was 12 and 4 respectively in Group A and Group B (p<0.05). About 38% female patients had PONV compared to 20% male patient in-group A. Also 27% female patients had PONV compared to 18% male patient in-group B. Conclusion: Prophylactic Ondansetron in a dose of 4 mg given near the end of surgery and prophylactic Dexamethasone in a dose of 8 mg given at the time of induction is highly effective in reducing the incidence of PONV for 4 hours and 8 hours respectively after surgery. Compared to male population female sex seems to be an independ nt risk factor for PONV.
Authors and Affiliations
Amitesh Pathak
Keywords
Related Articles
- EP ID EP466166
- DOI 10.21088/ijaa.2349.8471.42(pt-II)17.6
- Views 104
- Downloads 0
Comparison Between Interscalene Block using 0.5% Ropivacaine with Low dose Dexmedetomidine and using 0.5% Ropivacaine Alone in Upper Arm Surgeries: An Observational Study
Background: Interscalene brachial plexuses block is one of the delicately done widely used blocks for upper humerus and shoulder surgeries. Ropivacaine, a newer Local Anaesthetic (LA), has been increasingly used nowadays...
A Prospective Comparative Study of Efficacy and Safety of Dexmedetomidine as an Adjuvant to Caudal Levobupivacaine Versus Levobupivacaine Alone in Paediatric Patient
Background: As the day care surgery becomes popular, caudal epidural block has become routine intervention in children and infants. But the major limitation with this technique is duration of analgesia after single injec...
Assessment of Sensory and Motor Blockade by Bupivacaine with Dexmeditomedine or Fentanyl as Adjuvant in Lower Abdominal and Lower Limb Surgeries
Introduction: In the present-day practice of Anaesthesiology Bupivacaine is the most commonly used drug for subarachnoid block. Many adjuvants have been tried to improve the quality of analgesia and to prolong the durati...
Preventive Analgesic Efficacy of Intravenous Tramadol Versus Intravenous Nalbuphine for Elective Inguinal Hernia Repair Surgeries :Randomised Controlled Trial
Background Information: One of the challenges in postoperative care in a developing country is the non-availability of narcotics. Morphine and fentanyl have excellent analgesic action but they are difficult procure as th...
Oral Premedication in Paediatric Surgeries under General Anaesthesia with Ketamine versus Midazolam: A Comparative Study
Background: Pre-operative anxiety (anxiety regarding impending surgical experience) in children is a common phenomenon that has been associated with a number of negative behaviors during the surgical experience (e.g. agi...