COMPARATIVE STUDY OF LIPID PROFILE IN HYPOTHYROIDISM PATIENTS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 5
Abstract
Thyroid dysfunction is relatively a common disease which affects people, irrespective of their age and gender. Hypothyroidism is a graded disorder, it may be severe with obvious myxoedema, or mild to moderate or can be sub-clinical hypothyroidism, resulting in a generalized slowing down of the basal metabolic rate (BMR). It results from reduced secretion of total thyroxine (T4) and triiodothyronine (T3). Biochemical decrease in T4 and T3 lead to hyper secretion of pituitary thyroid stimulating hormone (TSH) and an amplified increase in serum TSH levels. This is a key laboratory finding, particularly in the early detection of thyroid failure. Thyroid hormones have significant effects on the synthesis, mobilization and metabolism of lipids. They affect serum cholesterol mainly by altering lipoprotein metabolism. The prevalence of hypothyroidism is increasing all over the world. Worldwide prevalence is estimated to be between 4.6% (USA) and 34% (Nepal).
Authors and Affiliations
Fuleshwar Mandal| Department of Biochemistry, Chitwan Medical College, Bharatpur, Nepal., Sanjay Yadav*| Department of Biochemistry, Chitwan Medical College, Bharatpur, Nepal., Suprita Gupta| Department of Biochemistry, National Medical College, Birgunj, Nepal., Pradip Hamal| Department of Laboratory Medicine, Chitwan Medical College, Bharatpur, Nepal., and Md. Nazrul Islam| Department of Physiology, Chitwan Medical College, Bharatpur, Nepal.
Keywords
Related Articles
- EP ID EP2284
- DOI -
- Views 355
- Downloads 34
CYTOPROTECTIVE EFFICACY OF DRDE-07 AND DRDE-30 AGAINST CISPLATIN INDUCED NEPHROTOXICITY
Aim: The objective of the study was to investigate the cytoprotective action of DRDE-07 and DRDE-30 against cisplatin induced nephrotoxicity in mice. Subjects and Methods: Randomly bred Swiss female mice (25-30 g) were s...
GALACTOSYLATED POLY (D, L-LACTIC-CO-GLYCOLIC ACID) NANOPARTICLES FOR LIVER TARGETED DELIVERY OF ACYCLOVIR
Introduction: The present study discusses d-galactose (Gal) –acyclovir- poly (D, L-lactic-co-glycolic acid) nanoparticles (Gal-PLGA-NPs) using galactose as an asialoglycoprotein receptor (ASGPR) ligand for hepatic targ...
SEROPREVALENCE OF HEPATITIS C VIRUS AMONG HEPATITIS B VIRUS POSITIVE PATIENTS ATTENDING TO TALODI HOSPITAL, SOUTH KORDOFAN, STATE, SUDAN.
Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) share common mode of transmission and both are able to induce a chronic infection. Dual HBV/HCV chronic confection is a fairly frequent occurrence, especial...
QUANTITATIVE DETECTION OF HIV-1 RNA - CLINICAL USEFULNESS IN DISEASE MANAGEMENT
The use of PCR for virus detection and quantification offers the advantages of high sensitivity and reproducibility combined with an extremely broad dynamic range. HIV-1 RNA levels in plasma of a patient is a significan...
NUTRIENT INTAKE AMONG SCHOOL GOING ADOLESCENT GIRLS IN LUCKNOW DISTRICT, INDIA
Background: Adolescent girls form an important vulnerable sector of population. Under-nutrition among adolescents is a serious public health problem internationally, especially in developing countries. Aim: To assess n...