COMPARATIVE STUDY OF LIPID PROFILE IN HYPOTHYROIDISM PATIENTS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 5
Abstract
Thyroid dysfunction is relatively a common disease which affects people, irrespective of their age and gender. Hypothyroidism is a graded disorder, it may be severe with obvious myxoedema, or mild to moderate or can be sub-clinical hypothyroidism, resulting in a generalized slowing down of the basal metabolic rate (BMR). It results from reduced secretion of total thyroxine (T4) and triiodothyronine (T3). Biochemical decrease in T4 and T3 lead to hyper secretion of pituitary thyroid stimulating hormone (TSH) and an amplified increase in serum TSH levels. This is a key laboratory finding, particularly in the early detection of thyroid failure. Thyroid hormones have significant effects on the synthesis, mobilization and metabolism of lipids. They affect serum cholesterol mainly by altering lipoprotein metabolism. The prevalence of hypothyroidism is increasing all over the world. Worldwide prevalence is estimated to be between 4.6% (USA) and 34% (Nepal).
Authors and Affiliations
Fuleshwar Mandal| Department of Biochemistry, Chitwan Medical College, Bharatpur, Nepal., Sanjay Yadav*| Department of Biochemistry, Chitwan Medical College, Bharatpur, Nepal., Suprita Gupta| Department of Biochemistry, National Medical College, Birgunj, Nepal., Pradip Hamal| Department of Laboratory Medicine, Chitwan Medical College, Bharatpur, Nepal., and Md. Nazrul Islam| Department of Physiology, Chitwan Medical College, Bharatpur, Nepal.
Keywords
Related Articles
- EP ID EP2284
- DOI -
- Views 378
- Downloads 34
Prevalence of MRSA nasal colonization among community members and healthcare workers at private and public hospitals in Khartoum State, Sudan.
Background:MRSA is a growing public health threat around the world. Until now, we are still unable to control the spread of staphylococcal infection and the development of resistance. Objectives: To determine the prevale...
A STUDY ON CORD BLOOD BILIRUBIN LEVELS IN A TERTIARY CARE CENTRE OF HARYANA IN INDIA
To determine the level of cord blood bilirubin in all healthy term newborns and asses its usefulness in predicting neonatal jaundice. Neonatal jaundice (NNJ) is an interesting, complicated and controversial clinical prob...
OXIDATIVE STRESS, ANTIOXIDANT STATUS AND 5’-NUCLEOTIDASE ACTIVITY IN CHRONIC HEPATITIS C AND ALCOHOLIC PATIENTS
Background: The present study was undertaken to estimate the 5’-nucleotidase enzyme in chronic hepatitis C and alcoholics. The oxidative stress, antioxidants and their correlation with 5’-nucleotidase was also included i...
ANALYSIS OF PRIMARY METABOLITES FROM VERTICILLIUMLECANII AND STUDIED ITS IMMUNOLOGICAL ASPECTS OF CRUDE PROTEASE AGAINST RAPITHER-AB
Objective- The objective of our study is to examine its primary metabolites (protein content) from dried powder of Verticilliumlecanii. In addition, immunological studies were conducted in order to analyzing the protease...
Permeation Enhancer for TDDS from Natural and Synthetic Sources: A Review
The transdermal drug delivery is now a promising route of drug delivery system. This route has potential advantage of avoiding hepatic first pass metabolism, decrease side effects, gastrointestinal effects, improved pati...