COMPARATIVE STUDY OF LIPID PROFILE IN HYPOTHYROIDISM PATIENTS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 5
Abstract
Thyroid dysfunction is relatively a common disease which affects people, irrespective of their age and gender. Hypothyroidism is a graded disorder, it may be severe with obvious myxoedema, or mild to moderate or can be sub-clinical hypothyroidism, resulting in a generalized slowing down of the basal metabolic rate (BMR). It results from reduced secretion of total thyroxine (T4) and triiodothyronine (T3). Biochemical decrease in T4 and T3 lead to hyper secretion of pituitary thyroid stimulating hormone (TSH) and an amplified increase in serum TSH levels. This is a key laboratory finding, particularly in the early detection of thyroid failure. Thyroid hormones have significant effects on the synthesis, mobilization and metabolism of lipids. They affect serum cholesterol mainly by altering lipoprotein metabolism. The prevalence of hypothyroidism is increasing all over the world. Worldwide prevalence is estimated to be between 4.6% (USA) and 34% (Nepal).
Authors and Affiliations
Fuleshwar Mandal| Department of Biochemistry, Chitwan Medical College, Bharatpur, Nepal., Sanjay Yadav*| Department of Biochemistry, Chitwan Medical College, Bharatpur, Nepal., Suprita Gupta| Department of Biochemistry, National Medical College, Birgunj, Nepal., Pradip Hamal| Department of Laboratory Medicine, Chitwan Medical College, Bharatpur, Nepal., and Md. Nazrul Islam| Department of Physiology, Chitwan Medical College, Bharatpur, Nepal.
Keywords
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