COMPARATIVE STUDY OF OVARIAN RESERVE TESTS AND OVARIAN RESPONSE TO CONTROLLED OVARIAN STIMULATION IN IVF
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 1
Abstract
BACKGROUND Controlled ovarian stimulation (COS) and optimum retrieval of fertilizable oocytes is crucial for IVF success. Ovarian response to COS is related to ovarian reserve (OR)- size of primordial follicular pool capable of maturing in the presence of gonadotrophins. There is a temporal fall in follicular pool from embryonic life onwards. The quest for ideal ovarian reserve test (ORT) resulted in several markers to measure ovarian response singly or in combination increasing the cost. The present study is a comparative evaluation of these tests with a view to ascertain the single most suitable test for ovarian response. The aim of the study is to compare and evaluate various ORTs with ovarian response and oocyte retrieval. The Objective of the study is to measure the hormonal and sonographic ovarian reserve markers and to evaluate which measure amongst them is superior in assessing the ovarian response and oocyte retrieval. MATERIALS AND METHODS Single centre retrospective cohort study of 183 women planned for first fresh cycle IVF with COS by GnRH agonist long protocol. Antral follicle count (AFC) and basal hormonal assay for FSH, LH, Oestradiol (E2), Inhibin-B and AMH were compared and evaluated for ovarian response and oocyte retrieval. RESULTS Serum AMH levels and Total AFC are significantly (p<0.001) lower in poor responders which is further confirmed by multivariate regression analysis (<0.05). It also shows that both AMH and AFC are significant (p<0.001) predictors of number of oocytes retrieved. CONCLUSION Serum AMH and Antral Follicular Count (AFC) are equally significant predictors of ovarian response and number of oocytes retrieved.
Authors and Affiliations
Karunakaran Sandeep, Srinivas Sangisapu
Keywords
Related Articles
- EP ID EP606975
- DOI 10.18410/jebmh/2019/1
- Views 94
- Downloads 0
ECTOPIC SPLEEN- A CASE REPORT
BACKGROUND Ectopic spleen is a rare clinical entity. It maybe asymptomatic or presents as abdominal discomfort. We report a case of ectopic spleen in a 25-year-old male patient presented as lower abdominal pain. On ultra...
EFFECT OF SMOKING 1-10 CIGARETTES PER DAY ON RESTING HEART RATE IN YOUNG ADULTS
BACKGROUND Smoking affects the cardiovascular system. Based on the hypothesis that nicotine by various mechanisms augments sympathetic outflow and/or attenuates parasympathetic activity which, directly or indirectly incr...
A CLINICAL STUDY OF MATERNAL DEATHS DUE TO PPH
OBJECTIVES: A study of maternal death conducted to evaluate various factors responsible for maternal deaths. To identify complications in pregnancy, a childbirth which result in maternal death, and to identify opportunit...
A STUDY OF EFFECTS OF ORAL CLONIDINE ON PREMEDICATION AND HAEMODYNAMIC CHANGES DURING LAPAROSCOPIC SURGERY
BACKGROUND Use of Clonidine as a premedicant started incidentally. Clonidine is a potent antihypertensive drug that suppresses RAAS. Clonidine may be beneficial during laparoscopy in patients with hypertension, cardiovas...
A RARE CASE OF PRIMARY MALIGNANT MELANOMA OF NASAL CAVITY
Malignant melanoma of the nose was first described by Lucke in 1869. The incidence of malignant melanoma in the nose and paranasal sinuses ranges between 0.5% and 1%. Mucosal variant is considered more aggressive with di...