Comparative Study of Post-Operative Analgesic Effects of Intramuscular Versus Transdermal Route of Diclofenac Sodium in Laparoscopic Cholecystectomy.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 12
Abstract
BACKGROUND: Transdermal patch of Diclofenac is as effective as intramuscular Diclofenac in relieving mild to moderate post-operative pain of elective laparoscopic cholecystectomy. However, transdermal route is noninvasive and with lower incidence of systemic adverse effects as compared to oral or parenteral routes. PATIENTS AND METHODS: In this prospective randomized clinical study, 60 patients of either sex with ASA-1 and ASA-2, undergoing elective laparoscopic cholecystectomy were randomly allocated to two groups, each of 30 patients. Group-1 patients received 75mgs (I/M) of Diclofenac sodium post incision and Group-2 patients received 100 mgs of Diclofenac transdermal patch, 6 hours prior to surgery. Post-operative analgesia was assessed using Visual Analogue Scale (VAS) and consumption of rescue analgesia. Additionally, Postoperative sedation was assessed by Ramsay sedation score (RSS) and Aldrete scoring. The data was statistically analyzed using various statistical tests and p- value of ˂0.005 was considered as statistically significant. RESULTS: Post-operative Visual Analogue Scale (VAS) at various time intervals, consumption of rescue analgesia using Tramadol (no. of boluses and dose) were compared among two groups, which were almost same in both groups and were statistically insignificant. CONCLUSION: The non-invasive route of transdermal patch of Diclofenac is as effective analgesic as intramuscular Diclofenac for mild to moderate post-operative pain of elective laparoscopic cholecystectomy.
Authors and Affiliations
Shabir A. Shabir, Basharat Farooq, G. A. Shah, Abdul Hamid, Mehak .
Keywords
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- EP ID EP421558
- DOI 10.9790/0853-1712010106.
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