Abstract

Objective: To evaluate and compare the efficacy of NB-UVB vs P-NBUVB vs PUVA therapies in patients with non-segmental vitiligo. To study the evaluation parameters and calculate the extent of repigmentation in response to these therapies on the basis of improvement in VASI scoring. Methods: 60 cases of previously untreated pa􀆟ents presen􀆟ng with non-segmental vi􀆟ligo and having more than 5% body surface area involvement were randomly allocated to receive either NB-UVB or P-NBUVB or PUVA with twenty patients in each group and response to therapy was compared in NB-UVB, P-NBUVB and PUVA groups with reference to percentage change in VASI scores. Therapeutic response was also done using type and colour of repigmentation and patient tolerance to therapies. Result: The dominant repigmentation seen in study is perifollicular. The percentage of improvement is greater in patients with vitiligo vulgaris in NB-UVB. Good colour match is observed in all patients on NB-UVB and The percentage change in repigmentation for patients treated with NB-UVB after comple􀆟on of 80 sessions of therapy is 63.15%, for P-NBUVB therapy is 61.83% and for PUVA therapy is 64.69% (P=<0.0001). Conclusion: No statistically significant difference is reported in percentage of repigmentation a􀅌er comple􀆟on of 80 sessions of therapy by all the three treatment modalities. The best color match is observed in the group on NB-UVB exposure. Side effects worsened progressively from NB-UVB to P-NBUVB and PUVA in that NBUVB was best tolerated.

Authors and Affiliations