Comparative Study of Sevoflurane and Sodium Thiopentone in Electroconvulsive Therapy
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 4
Abstract
Sodium thiopentone is most commonly used agent for electroconvulsive therapy (ECT) in India, but have side effects like prolonged awakening time, arrhythmias and laryngeal spasm. Therefore keeping into view the requirements of ideal and safe induction agent for anaesthesia in ECT, new modality of induction agent like sevoflurane have been tried. This is a randomised prospective crossover study to compare recovery profile and hemodynamics of Sevoflurane and Thiopentone sodium. 100 patients who underwent ECT were divided into two groups Group-T & Group S. Group-T patients were induced with Inj. sodium thiopentone and inj.succinyl choline. In group-S, induction was done with Sevoflurane 8%. After loss of eye lash reflex inspired sevoflurane concentration was reduced to 2% and inj. succinyl choline 0.5 mg/kg was administered intravenously. Onset of action, seizure duration, recovery time, hemodynamic effects and side effects were noted. Power of study was 80% and p-value <0.05 was considered significant. All data were represented as mean ± SD. The seizure duration was shorter in group S compared to Group T. The rise in heart rate (HR) was significantly more in group T as compared with group S. The rise in mean blood pressure (MBP) after delivering ECT was more in group S as compared with group T. The mean time of eye opening and response to verbal command was shorter in group S (p=0.0129, p=0.0356 respectively) than group T. Conclusions: Sevoflurane induction was well tolerated by our patients, and its induction was associated with faster recovery. Sevoflurane does not compromise seizure induction and may offer a stable heart rate
Authors and Affiliations
Dr Chetna Jadeja
Keywords
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