Comparative Study of Single Fraction and Multiple Fraction Palliative Radio Therapy for the Treatment of Bone Metastasis in Multiple Center of Bangladesh.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background: The main goal of palliative radiation treatment is to relief pain or dysfunction caused by bone metastasis. Bone metastasis is very much painful in advanced cancer. This observational study aims to compare the efficacy of different radiation fractionation schedules. Objective: To compare the role of single fraction and multiple fraction radiotherapy in the management of metastatic bone pain. Method: All patients were explained about the aims, objectives, procedure, risk and benefits of the study. Written informed consent was taken from each patient. Sampling technique was simple random sampling. Every odd number of patients was taken in Group A & every even number patient was taken in Group B. Group A: patients were treated with single (8 Gy) fraction radiotherapy and Group B: patients were treated with multiple fraction (30 Gy) radiotherapy i.e.300 cGy per fraction in 10 fractions, 5days a week for two weeks by telecobalt or orthovoltage machine. The responses were, Complete response: Absence of pain. Partial response: decrease of pain. The response to radiotherapy was recorded at the end of treatment, 7days, 14days, 21days, 28days and during the follow-up visits. Result: The total number of 90 patients of metastatic bone disease were studied in two groups. Group A included 44 patients received a single fraction of 8 Gy tumor dose and Group B included 46 patients who received 30 Gy tumor dose in 10 fractions over two weeks. Onset of pain relief was 68% in Group A and 67.4% in Group B after completion of 4th weeks radiation. After 8th weeks of radiation 81.8% in Group A and 86% in Group B are relieved from pain. Complete response in Group A 45% and in Group B 52%, partial response in Group A 40% and in Group B 37% and overall distribution of no response in Group A 18% and in Group B 7%. Conclusion: For metastatic bone pain single fraction palliative radiotherapy and multiple fractions palliative radiotherapy is almost same in efficacy.
Authors and Affiliations
Bhuiyan MZR, Rahman A, Rassell Md
Keywords
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- EP ID EP467024
- DOI 10.9790/0853-1802054651.
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