COMPARATIVE STUDY OF THE EFFECT OF CLOMIPHENE CITRATE AND LETROZOLE FOR INDUCTION OF OVULATION IN PRIMARY INFERTILITY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 37
Abstract
BACKGROUND About 40% cases of infertility are due to failure of ovulation.1 Ovulation has two major components, folliculogenesis and true ovulation.2 Many a protocol has been envisaged using a type of permutation and combination mode by various hormones and drugs. A few among them are FSH, clomiphene citrate and letrozole. Aim: In the present study, effect of clomiphene citrate is compared with letrozole for induction of ovulation. MATERIALS AND METHODS This is a non-randomised controlled trial study conducted during a period of over one year from 10 December 2016 to 31 March 2018, where 100 cases of primary infertility with failure of ovulation were selected. Cases were equally divided into two groups. Letrozole (n= 50) and clomiphene (n= 50) were given to each group. Folliculogenesis and ovulation were monitored by ultrasound starting from the eleventh day of the first menstrual date. The sample size estimation was also done at convenience. RESULTS Ovulation rate with letrozole is 64% and that with clomiphene citrate is 46%, which is statistically significant (p < 0.001). CONCLUSION Letrozole is superior to clomiphene citrate to affect ovulation in case of primary infertility.
Authors and Affiliations
Leela G. R, Pandurangaiah R, Asokan K. M
Keywords
Related Articles
- EP ID EP547987
- DOI 10.14260/jemds/2018/908
- Views 72
- Downloads 0
FIBROMA OF METACARPAL- RARE PRESENTATION
Benign and malignant affections of bone is not uncommon entity. Both types of lesions are seen in both sexes and all age groups. Ossifying fibroma is a rare, benign, slow-growing bone tumor. Tumor has a high re...
PREVALENCE OF CANDIDA AND SALIVARY FLOW RATES IN ORAL SUBMUCOSAL FIBROSIS PATIENTS
BACKGROUND Candida species belong to the normal microbiota of an individual’s mucosal oral cavity, gastrointestinal tract and vagina. The alteration in the homeostasis between Candida, host immune system and normal oral...
TWO YEAR HOSPITAL BASED STUDY ON RHINOSPORIDIOSIS IN AND AROUND DHANBAD DISTRICT, JHARKHAND, INDIA
BACKGROUND Rhinosporidium seeberi is an organism responsible for Rhinosporidiosis. Most of the time, it will cause infection to nasal mucosa, whereas disseminated infection can also be seen in some cases. Highest inciden...
ASSESSMENT OF CLINICO-RADIOLOGICAL OUTCOMES OF OPERATED CASES OF INTRA: ARTICULAR LOWER END RADIUS FRACTURES
[b] BACKGROUND[/b]: Distal radius fractures with intra-articular extension are complex injuries which have been treated by various methods. The study was to evaluate the outcome of operative management of dist...
VALIDATION OF RIPASA SCORING SYSTEM FOR DIAGNOSIS OF ACUTE APPENDICITIS
BACKGROUND Acute appendicitis is one of the frequently encountered surgical emergencies. Although common, due to a variety of other gynaecological and genitourinary inflammatory conditions presenting in a similar fashion...