Abstract

Objective: To determine the total phenolics and flavonoids and to evaluate antioxidant and antimicrobial activities of different extracts from fruits of Datura metel (D. metel). Methods: Different crude extracts from the fruits of D. metel were subjected to determination of total phenolics, flavonoids, antioxidant and antimicrobial activities by established methods. Results: The total phenolics results showed that ethyl acetate extract was the most efficient (60.26%) compared to hexane, chloroform, butanol and methanol extracts which had phenolic contents of 50.08, 35.50, 52.54 and 26.49%, respectively. Almost similar results were obtained from the fruits crude extracts for total flavonoids and results found that methanol crude extract was the highest (1.71%) compared to other crude extracts. The antioxidant activity results showed that methanol extract acted the highest activity compared to other extracts and in the order of methanol>ethyl a cetate>hexane>chloroform>butanol extract. All extracts were displayed moderate antibacterial potential against the tested bacteria such as Staphylococcus aureus, Escherichia coli and Pseudomonus aeruginosa in the range of 0%-10%. Conclusions: The results of this present study clearly showed that the crude extracts of D. metel demenstrated antimicrobial and antioxidant activities and it may act as potential antioxidant sources for human biological system.

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