COMPARATIVE STUDY ON LIPID PEROXIDATION AND ANTIOXIDANT VITAMINS E AND C IN FALCIPARUM AND VIVAX MALARIA
Journal Title: Indian Journal of Clinical Biochemistry - Year 2006, Vol 21, Issue 2
Abstract
Reactive oxygen species are thought to be involved in the pathogenesis of Malaria. To assess the extent of oxidative stress, a study was conducted in patients with Plasmodium falciparum malaria and Plasmodium Vivax malaria. Plasma Thiobarbituric acid reactive substances(TBARS) were measured to assess the degree of lipid peroxidation. Antioxidant status was measured by estimating the levels of Vitamins E and C. Results were compared with age and sex matched control subjects. This study suggests that plasma TBARS levels were significantly increased in malaria patients. The patients with P. falciparum infection showed significantly increased levels of lipid peroxides when compared to P. vivax malaria. The antioxidant Vitamins E and C were decreased significantly in malaria patients in both the groups. Maximum decline in Vitamin C was observed in P. vivax malaria. Therefore it is been hypothesized that antioxidant Vitamins E and C could provide protection against the oxidative stress induced by malaria.
Authors and Affiliations
Prasannachandra , Vivian D’Souza , Benedicta D’Souza
Keywords
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