Comparative Study on Neutrophil to Lymphocyte Ratio as Predictor of Severe Pre-Eclampsia between Normotensive and Pre-Eclamptic Women
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 2
Abstract
Background: Pregnancy-induced hypertension (PIH) is the most common medical disorder of pregnancy contributing significantly to maternal/fetal morbidity and mortality. It is common practice to investigate the etiology of symptoms and monitor disease activity by monitoring markers of inflammation. However, information related to leukocytes count and its differentials is limited in patients with pre-eclampsia. Based on these conflicting data, the current study was conducted in order to compare neutrophil to lymphocyte ratio (NLR) in pregnant women with and without pre-eclampsia. Materials & Methods: This is a hospital based comparative longitudinal study on 50 healthy pregnant women (controls) and 50 women with pre-eclampsia (cases) attending antenatal opd and admitted in labour room and fulfilling inclusion /exclusion criteria and give written and informed consent in obstetrics and gynaecology department S.M.S. Medical College Jaipur from May 2016 to May 2017. Results: Our study showed that the mean age of pre-eclamptic group was 27.60±6.47 years and in control group was 26.98 ± 6.33 yrs. Systolic and diastolic BP was significantly higher in (P<0.0001*** each) in pre-eclamptic group as compared to control group. Our study showed that the mean value of hemoglobin and WBC was non-significant (P=0.172 & P= 0.051 respectively) but neutrophils, lymphocyte and NLR was statistically significant (P=0.025**, P= 0.04** & P=0.001** respectively) when compare to between groups. Conclusion: We concluded that the neutrophil to lymphocyte ratio is increased in women who have pre-eclampsia, this may serve as a predictor for the disease. Hence establishing cost-effective bio-markers help in early prediction of disease which in turn helps in early treatment and slow down progression of disease.
Authors and Affiliations
Megha Agrawal, Reena Meena, Anju Sharma
Keywords
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- EP ID EP538988
- DOI 10.21276/ijmrp.2018.4.2.035
- Views 65
- Downloads 0
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