Comparative Study on Safety and Efficacy of Low-Molecular-Weight Heparins with Unfractionated Heparins in the Management of Coronary Artery Disease in A Rural Tertiary Care Hospital
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 4
Abstract
Introduction: Low-molecular-weight heparin (LMWH) fractions are prepared from standard unfractionated heparin (UFH) and are thus similar to UFH in many aspects. Aim: This study compares the safety and efficacy of LMWH with UFH in the management of acute coronary artery disease. Materials and Methods: A total of 133 patients admitted in critical care unit with a history of chest pain and associated electrocardiogram finding were included administered LMWH and UFH for 5 days and studied. Results: Compared to UFH group of patients, the average prothrombin time was higher. 4% of patients had thrombocytopenia in UFH and no events seen in LMWH. Conclusion: Antithrombotic therapy with LMWH was safer and more effective than UFH in reducing the incidence of ischemic events in patients with unstable angina or myocardial infarction in the early phase.
Authors and Affiliations
S Selvamuthukumaran
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