Comparative Study to Know Efficacy of Topical Minoxidil (2%) Versus Topical Diltiazem (2%) in Chronic Anal Fissure Healing
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Chronic Anal fissure (CAF) is an elliptical ulcer in the anal canal extending from dentate line to the anal verge with sentinel pile or hypertrophied papilla. It is associated with hypertonia of the internal anal sphincter and pain; surgery to reduce internal anal sphincter hypertonia has been the standard treatment for anal fissure. Since, minoxidil, a potassium channel opener, induces smooth muscle relaxation and vasodilatation. It has been found that this drug could hasten the healing of anal fissure. The objective of the present study was to compare and evaluate the efficacy of topical minoxidil (2%) versus topical diltiazem (2%) in management of CAF. Material and methods: This prospective comparative study was conducted in 100 patients with CAF. They were randomly divided into two groups, A and B. Group A received local application of ointment containing 2% minoxidil and group B recieved 2% diltiazem. The patients were advised to visit the hospital every alternate week for a period of 6 weeks. Results: Complete fissure healing rate was 74.5% in minoxidil group against 50% in diltiazem group with p value 0.030. The pain relief was also good as 65.9% patients in minoxidil group and 15.9% patients in diltiazem group got relieved from this painful symptom over the 6 weeks time. Minoxidil controls bleeding per rectum (BPR) in 91.5% patients while 91.1% patients got relieved from BPR in diltiazem group. Recurrence rate was found 6.4% in minoxidil group as compared to 11.4% in diltiazem group. Minoxidil produce side effects like hypertrichosis, headache and perianal dermatitis. Minoxidil produce headache in 2.12% of the patients as compared to Diltiazem in 4.54% of the patients. Conclusion: Minoxidil 2% topical application is a good alternative in CAF healing in place of Diltiazem 2% with few side effects which could be ignored in regard to benefit of CAF healing.
Authors and Affiliations
Rachan Lal Singla, Sanjay Yadav, Paras Kumar Pandove, Bimaljot Singh
Keywords
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