Comparative Study to Know Efficacy of Topical Minoxidil (2%) Versus Topical Diltiazem (2%) in Chronic Anal Fissure Healing
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Chronic Anal fissure (CAF) is an elliptical ulcer in the anal canal extending from dentate line to the anal verge with sentinel pile or hypertrophied papilla. It is associated with hypertonia of the internal anal sphincter and pain; surgery to reduce internal anal sphincter hypertonia has been the standard treatment for anal fissure. Since, minoxidil, a potassium channel opener, induces smooth muscle relaxation and vasodilatation. It has been found that this drug could hasten the healing of anal fissure. The objective of the present study was to compare and evaluate the efficacy of topical minoxidil (2%) versus topical diltiazem (2%) in management of CAF. Material and methods: This prospective comparative study was conducted in 100 patients with CAF. They were randomly divided into two groups, A and B. Group A received local application of ointment containing 2% minoxidil and group B recieved 2% diltiazem. The patients were advised to visit the hospital every alternate week for a period of 6 weeks. Results: Complete fissure healing rate was 74.5% in minoxidil group against 50% in diltiazem group with p value 0.030. The pain relief was also good as 65.9% patients in minoxidil group and 15.9% patients in diltiazem group got relieved from this painful symptom over the 6 weeks time. Minoxidil controls bleeding per rectum (BPR) in 91.5% patients while 91.1% patients got relieved from BPR in diltiazem group. Recurrence rate was found 6.4% in minoxidil group as compared to 11.4% in diltiazem group. Minoxidil produce side effects like hypertrichosis, headache and perianal dermatitis. Minoxidil produce headache in 2.12% of the patients as compared to Diltiazem in 4.54% of the patients. Conclusion: Minoxidil 2% topical application is a good alternative in CAF healing in place of Diltiazem 2% with few side effects which could be ignored in regard to benefit of CAF healing.
Authors and Affiliations
Rachan Lal Singla, Sanjay Yadav, Paras Kumar Pandove, Bimaljot Singh
Keywords
Related Articles
- EP ID EP429475
- DOI -
- Views 90
- Downloads 0
Doppler Waveform Study: A Useful Diagnostic and Prognostic Tool in IUGR
Introduction: Intrauterine growth restriction (IUGR) is responsible for significant proportion of perinatal morbidity and mortality in developing countries. Doppler waveform study of fetal blood vessels and uterine arter...
Screening of Cervical Cancer by Artificial Intelligence based Analysis of Digitized Papanicolaou-Smear Images
Introduction: Cervical cancer is one of the main causes of female mortality due to cancer in the world. Researchers have suggested that by regular cervical cancer screening its incidence and mortality a can be reduced by...
Knowledge, Attitude and Practice of Diabetes amongst Rural Population - An Institutional based Study
Introduction: Type 2 diabetes mellitus is becoming a global epidemic which causes significant disability, premature death and is responsible for huge medical costs. The increase in diabetes amongst low-resource countries...
Scalp Reconstruction in a Tertiary Care Hospital in Jharkhand, India
Introduction: Loss of scalp can be covered by various methods like skin grafting, local flaps, distant flaps, free flap or tissue transfer. Every method has some advantages and some disadvantages. Material and Methods: O...
Correlation of HbA1c with Mortality and severity in Acute Coronary Syndrome
Introduction: Coronary Artery Disease (CAD) has emerged as the single most important cause of death worldwide and as well as in India. Diabetes Mellitus (DM) is a major risk factor for CAD and there appears to be a grade...