Role of KI-67 and P16 as Markers of Prognostic Indices in Premalignant and Malignant Lesions of Cervix
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 10
Abstract
Introduction: Since cervical cancer is highly attributed to the effects of HPV, an infectious agent, it can either be prevented or treated at a pre-invasive stage there by reducing morbidity and mortality; hence the need for additional biomarkers and parameters of cell proliferation and cell death as important diagnostic and prognostic tools. This study was done to evaluate the proliferative indices in cervical pre cancerous and cancerous lesions using Ki-67 and p16 as bio markers. Material and Methods: A total of 50 cases including CIN- 1,CIN-2,CIN-3 and malignancy of the cervix were evaluated. Strong nuclear positivity for Ki-67was considered positive. The scoring was graded 1,2,3 for 10-30%,30-50% and>50%. Staining intensity for p16(nuclear or/and cytoplasmic staining) was done and the results were categorized as Grade 1,2,3 for 1-10%,10-50% and >50%positive cells. Results: Ki-67 and p16 expression were seen in CIN-I,II,III and squamous cell carcinomas of the cervix.Ki-67 expression was in increasing grades from CIN to carcinoma.p16 had a better expression in high grade intra epithelial lesions(60-80%) and malignancies (100%)of the cervix compared to low grade dysplasias(21%). Conclusion: Thus Ki-67 and p16 expression in pre malignant and malignant lesions of the cervix can be used in conjunction with the histo morphological features to study their proliferative potential.
Authors and Affiliations
Dina Mary M, Shantaraman K
Keywords
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