Memantine add-on to Atypical Antipsychotics for Treatment of Negative Symptoms in Schizophrenia
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 7
Abstract
Introduction: Studies on the role of adjunctive memantine to atypical antipsychotics in treatment of negative symptoms of schizophrenia have shown conflicting results. In view of the above, the present study was carried out to find the efficacy of memantine as add-on to ongoing atypical antipsychotics in treatment of negative symptoms in schizophrenia patients. Material and Methods: The number of patients of schizophrenia selected were 40, based on specified inclusion criteria. They were divided into 2 groups of 20 each. Group 1 was the study group which received memantine in addition to their on going antipsychotics while, group 2 was the control group and received placebo and their on going atypical antipsychotics. PANSS was administered at baseline and after 8 weeks results were analyzed statistically. Results: Both the groups were matched as far as various sociodemographic variables, duration of illness and PANSS scores at baseline were concerned. After 8 weeks, there was no significant difference in the PANSS negative syndrome scale scores between the 2 groups. Conclusion - The main cause of disability in schizophrenia patients are the negative and cognitive symptoms. They are generally resistant to the current pharmacological treatments, including atypical antipsychotics. From current study we can say that Memantine add-on to atypical antipsychotics had no advantage over placebo.
Authors and Affiliations
Pavan Kumar Pardal, Abhilasha Gupta
Keywords
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