Compare the Efficacy of Prochlorperazine and Granisetron in Patients Undergoing Total Abdominal Hysterectomy
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 10
Abstract
Aim: To compare the effectiveness of mouth dissolving antiemeticsprochlorperazine and granisetron in the prevention of postoperative nausea and vomiting in patients undergoing abdominal hysterectomy under spinal anaesthesia Materials and Methods: A total number of 50 cases of ASA Gr.I and Gr. II were taken into a double blind randomized study and divided into two groups. 25 of them received Granisetron 1mg mouth dissolving tablet and the other 25 patients received Prochlorperazine 5mg mouth dissolving tablet for preventing postoperative nausea and vomiting and observed for a period of 24 hours. Results: There were no statistically significant differences between the groups with respect to patient characteristics, type of surgery and duration of anesthesia. Administration of Prochlorperazine and Granisetron 60min before surgery, effectively controlled nausea and vomiting during early postoperative period i.e., within 6 hours after surgery. Postoperative nausea and vomiting in the 6 – 24 hours postoperative period was significantly lower with Granisetron when compared to Prochlorperazine. (p value <0.01) Conclusion: Administration of Granisetron 1hr before surgery was superior to Prochlorperazine in long term prevention of postoperative nausea and vomiting following Total abdominal hysterectomy under spinal anesthesia.
Authors and Affiliations
Sarita Chandapet
Keywords
Related Articles
- EP ID EP548572
- DOI 10.21088/ijaa.2349.8471.51018.18
- Views 94
- Downloads 0
Coming out of our Comfort Zone
Conventionally, anesthesiologists practice as perioperative physician, providing preoperative, intraoperative and postoperative care to their surgical patients. Though primarily they focus on providing anesthesia to the...
A comparative Clinical Study of Subarachnoid Block With 0.75% Isobaric Ropivacaine 15 mg & 0.5% Hyperbaric Bupivacaine 8 mg Patients for Caesarean Section
Background: Ropivacaine is a local anaesthetic agent which is a long acting amide, a pure S (-) enantiomer of propivacaine. It has reduced potential for neuro and cardiotoxicity and safer than bupivacaine. This drug is l...
A Comparative Study of Butorphanol Versus Pethidine with Bupivacaine Heavy During Spinal Anaesthesia
Background: Management of postoperative pain is essential for the smooth recovery of the patients. Intrathecal opioids are commonly used adjuvants to bupivacaine heavy for improving the quality of spinal anaesthesia. The...
Effect of Premedication with Intravenous Clonidine in Modulating the Haemodyanamic Responses during Laparoscopic Surgeries
Context: Pneumoperitoneum during laparoscopic surgeries leads to adverse effects on cardiovascular physiology which in turn compromises tissue perfusion. Aims: To study the effect of premedication with intravenous cloni...
Comparison of Recovery Profile of Sevoflurane and Desflurane in Patients Undergoing Elective Neurosurgical Procedures
Aim: The primary objective of the study was to compare the early post-operative recovery profile of Sevoflurane with Desflurane in adult patients undergoing elective neurosurgical procedures, with respect to emergence ti...