Comparing Genes and Phenomenology in the Major Psychoses: Schizophrenia and Bipolar 1 Disorder
Journal Title: Schizophrenia Bulletin - Year , Vol 34, Issue 4
Abstract
Twin studies show that the concordance rate for schizophrenia is higher in monozygotic twins (47%–56%) than in dizygotic twins (12%–16%), suggesting a strong heritability component for the illness. Some studies reported the concordance rates for monozygotic twins over 80% in cases of severe schizophrenia with typical core symptoms.33 Further, twin studies suggest that a schizophrenia diagnosis in one twin increases risk for both schizophrenia and affective psychosis in the cotwin.34,35 An overlap in genetic risk for schizophrenia, schizoaffective, and manic syndrome is also suggested by a report, based on the Maudsley twin series: the maximum monozygotic/dizygotic concordance ratio was produced by a combination of schizophrenia, affective disorder with mood-incongruent psychotic features, schizotypal personality disorder, and atypical psychosis.
Authors and Affiliations
Elena Ivleva, Gunvant Thaker, Carol A. Tamminga
Keywords
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- EP ID EP683286
- DOI 10.1093/schbul/sbn051
- Views 86
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