Comparing the adverse impact of Ethanolic Root Bark and Leaf Extracts of Rauwofiavomitoria(apocynaceae) on Cerebellar Glycogen in Adult Wistar Rats
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 9
Abstract
Abstract:The use of herbal medicine in Nigeria is on the increase but unknowingly to consumers, these herbal products may pose severe and devastating health hazards. This study was aimed at studying the adverse impacts posed by either the ethanolic extract ofroot back or leaf extract of Rauwofiavomitoria on cerebellar glycogen. In this study, 30 adult Wistar rats were used and were randormly divided into 6 groups (A, B, C, D and E; n =5). Identification of Glycogen was determined using Periodic Acid Schiff method (PAS). From this investigation, there was a marked increase in the staining intensities of the experimental groups. The staining intensity of PAS was higher in the groups C and D which were given 200mg/kg and 300mg/kg of ethanolic extract of Rauwofiavomitoria root-bark when compared to groups E and F which received 200mg/kg and 300mg/kg of ethanolic leaf extract of Rauwofiavomitoria. Findings in this study suggest a dose-dependent accumulation of glycogen in the neurons of cerebellum, especially in the Purkinje cells. This could be due to the effects of indole alkaloid constituents (reserpine) of Rauwolfiavomitoria on glycogen synthesis and utilization. Keywords:PAS, Rauwofiavomitoria, cerebellum, glycogen, root bark, leaf extract
Authors and Affiliations
Akaninyene M. Okon, Clementina F. Iniodu, Gabriel D. Edem, Ekaette P. Akpan
Keywords
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