Abstract

Objectives: To evaluate whether a 24-hr urine collection for measuring urinary albumin excretion in preeclamptic women can substitute 12-hr collection or spot urine samples. Materials and Methods: The present study was conducted in the Department of Obstetrics and Gynaecology SMGS Hospital, Government Medical College, Jammu for a period of one year from October 2013 to September 2014. It was a prospective study carried out on 100 preeclamtic patients having urine albumin at least 1+ using dipstick test. From each women one spot urine sample, two 12-h sample, and one 24-h urine were collected. Total collection time for 24 hour urine collection was started on the first morning after admission to the hospital and all samples were collected within a day. For each sample, urine albumin concentrations in milligram per litre were analyzed by colorimetric method. The data was presented as mean±SD. The correlation between one spot and two 12-hour and 24-hour urine samples was examined using Pearson correlation test. Results: Out of the enrolled 100 cases, mean age of the participants was 27.14 year (SD 4.477 years). The majority of patients were primigravida (69%). Mean systolic BP was 153.8 mm of Hg (SD 14.87mm of Hg) while mean diastolic BP was 102.46 mm of Hg ( SD 9.82mm of Hg) . Mean 24-h urinary albumin excretion was 734.35 mg/L (SD 687.860mg/L),mean spot urinary albumin excretion was 1063.66mg/L (SD 1009.340). Mean 12-h day urinary albumin excretion was 733.52 mg/L (SD 677.970 mg/L), mean 12-h night urinary albumin excretion was 752.67 mg/L (SD 803.56 mg/L). The differences between the 24-hour collection and the spot samples were too great to be acceptable in clinical practice.Albumin concentrations in a 12-h (day) and 12-h (night) interval collection fitted closely with the 24-h collection. Conclusion: The study concluded that the gold standard 24-h urinary assessment of albuminuria in preeclamptic women could be substituted with a 12-h collection.

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