Abstract

Aim: To evaluate the diagnostic value of PAPP-A and CK-MB in early diagnosis of ACS. Material and Methods: It is a single-center, prospective, clinical study. There were totally 152 cases. At the end of the study the levels of troponin-T, CK-MB, PAPP-A and IMA in the different groups were compared. Results: There were 13 patients with STEMI, 53 patients with NSTEMI/UAP and 80 patients with non-specific ECG findings. When we consider the definitive diagnosis; there were 8 patients with STEMI, 36 patients with NSTEMI, 23 patients with UAP, 17 patients with SAP and 68 patients with non-coroner chest pain. In our study, the most specific parameter at the highest sensitivity for the patients with the chest pain within the first hours (0-2 hour, 2-4 hour) was IMA. (Sensitivity/specificity; 100/30.7, 93.7/52.3 respectively). Conclusion: According to our results, PAPP-A and IMA cannot be used as an diagnostic tool like troponin-T and CK-MB in ACS. Also IMA cannot be used as an ideal screening test in the diagnosis of ACS during the early period of chest pain. Still, IMA is more useful diagnostic biochemical marker than troponin-T, CK-MB and PAPP-A as a screening test in detecting ACS during the first hours.

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