Comparision of High Dose Rocuronium with Succinylcholine for Intubation
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 2
Abstract
Context: Succinylcholine has extremely rapid onset of action and its shorter duration of action make it the ideal muscle relaxant for rapid sequence intubation. Because of these adverse effects and risks associated with succinylcholine, extensive laboratory research has been undertaken to synthesize a nondepolarising neuromuscular blocking agent. Rocuronium a structural analogue of vecuronium was recently synthesized and has been demonstrated to have fastest onset of action compared to any nondepolarizing neuromuscular blocking agent. Aims: To compare the two muscle relaxants i.e., succinylcholine and rocuronium on tracheal intubating conditions. Settings and Design: This study was a double blinded, randomized, controlled trial, carried out at tertiary care centre in India between March 2014 and June 2016. The sample size for this study was calculated to be 45 in each group. Methods and Material: All patients included in the study were premedicated with inj.glycopyrolate 0.2mg intramuscularly ½ hr before surgery. General anaesthesia was induced with propofol 2mg/kg and fentanyl 2mg/kg intravenously. All Group A patients received succinylcholine (2mg/kg) and all patients of group B received rocuronium (1.2 mg/kg). After giving the muscle relaxant, patient was ventilated with oxygen, nitrous oxide, and isoflurane for 90 seconds. The intubating condition is evaluated and scored according to the four step scale proposed by Goldberg and colleagues. Statistical Analysis Used: Analysed using Microsoft Excel 2010 and SPSS (Version 19) software. All data on categorical variables were presented as frequencies and percentages. Chi square test was used to compare the frequencies and percentages. All the statistical analysis were carried out at 5% level of significance and p value <0.05 was considered significant. Chi square test was used to compare the frequencies and percentages. Results:There were no statistically significant changes in heart rate, systolic and diastolic between the succinylcholine group (A) and rocuronium group (B) at various time intervals. In succinylcholine group (A) 95.5% had excellent intubating conditions at 90 seconds. In rocuronium group (B) 93.3% of patients had excellent intubating conditions at 90 seconds. All the patients of rocuranium group could be intubated at 90 seconds. Conclusion: Rocuronium does not produce significant haemodynamic changes.Higher dose (1.2 mg) of Rocuronium would be suitable for rapid intubation conditions.
Authors and Affiliations
Lata D. Shetty
Keywords
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- EP ID EP465347
- DOI 10.21088/ijaa.2349.8471.4217.22
- Views 103
- Downloads 0
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