Comparison Of Antimicrobial Susceptibility Pattern Of Biofilm Producing And Non-Biofilm Producing Staphylococci Isolated From Various Clinical Samples Of Patients From A Tertiary Care Hospital
Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 2
Abstract
Biofilms have great significance in medical field as they decrease susceptibility to antimicrobial agents. We tested 242 clinical isolates of staphylococci for biofilm production by Tissue culture plate method (TCP) and compared the Antimicrobial Susceptibility Pattern of biofilm producing and non-biofilm producing staphylococci. Association of Multidrug Resistance with biofilm formation was also observed. Further speciation of biofilm positive staphylococci was done by MicroScan system. Biofilm producers were 142 (58.6%) out of 242 staphylococcal isolates, of which 81 (57.04%) biofilm producers were CNS and 61 (42.96%) were CPS. Maximum biofilm production was seen by S.epidermidis isolates i.e. 72 (50.70%), followed by 61 isolates (42.96%) of S.aureus, 5 (3.52%) isolates of S.haemolyticus, and 2 isolates (1.41%) of S.lugdunensis. Only 1 isolate (0.70%), each of S.saprophyticus and S.schleiferi formed biofilm. The biofilm producing staphylococcal isolates showed higher resistance to ciprofloxacin, clindamycin, erythromycin and gentamicin as compared to non-biofilm producing staphylococcal isolates. Vancomycin and linezolid were 100% effective drugs against both groups. A higher prevalence of Multidrug resistant isolates was observed among the biofilm producers (92.95%) than the non-biofilm producers (60%). In our study Vancomycin and linezolid were found to be 100% sensitive against biofilm producing staphylococci, hence we suggest that these drugs can be used in treating staphylococcal biofilm infections
Authors and Affiliations
Dr. As tha, Dr. Suman Rishi
Keywords
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