COMPARISON OF BOLUS INTRAVENOUS EPHEDRINE AND PHENYLEPHRINE FOR MAINTENANCE OF ARTERIAL BLOOD PRESSURE IN CAESAREAN SECTION DURING SPINAL ANAESTHESIA
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2016, Vol 3, Issue 19
Abstract
CONTEXT (BACKGROUND) Hypotension following spinal anaesthesia is a common problem. Preloading with IV Fluids alone is not sufficient, because inadequately treated hypotension during Caesarian section causes undue effects on both mother and fetus. So concomitant use of vasopressor drugs to treat spinal hypotension proved useful and well established. AIM To compare the efficacy of intravenous phenylephrine versus intravenous ephedrine for correction of intra operative hypotension following spinal anaesthesia for elective as well as emergency caesarean sections. DESIGN A randomized controlled study of patients undergoing surgery under spinal anaesthesia for elective and emergency caesarean section. METHODS & MATERIALS The present study includes 100 patients divided into two groups each of 50 patients. Group P (Phenylephrine group), Group E (Ephedrine group.) The baseline heart rate, systolic, diastolic and mean blood pressures were measured. Whenever Hypotension ( fall in BP >20% of baseline or less than 90 mm of Hg )occurred, Group P received Phenylephrine 40 mcg and Group E received 6 mg Ephedrine as intravenous bolus. STATISTICAL ANALYSIS Was done using Student’s t test and Mann-Whitney test. ‘p’ value of less than 0.05 was considered to be statistically significant RESULTS & CONCLUSION Phenylephrine in a dose of 40 microgram is more efficacious in comparison to Ephedrine 6 milligrams in maintaining arterial blood pressure following hypotension after spinal anaesthesia in Caesarean section. Phenylephrine has a quicker peak effect (within 2 minutes of IV bolus) as compared to Ephedrine (within 10 minutes of IV bolus) APGAR Score at 1 and 5 minutes is comparable in both Group P and Group E.
Authors and Affiliations
Rama Krishna Reddy Mudiganti, Rajkumar J, Aruna Subhash T
Keywords
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- EP ID EP233860
- DOI 10.18410/jebmh/2016/180
- Views 85
- Downloads 0
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