Comparison of Clonidine and Dexmedetomidine for Attenuation of Hemodynamic Responses of Intubation and Pneumoperitoneum During Laparoscopic Cholecystectomy: A Randomized Double Blind Placebo Controlled Trial
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 1
Abstract
Hemodynamic derangements, associated with intubation and pneumoperitoneum during laparoscopic surgery can be attenuated by use of α2 agonist drugs like clonidine and dexmedetomidine. To compare the attenuating effects of clonidine and dexemedetomidine on hemodynamic responses during intubation and pneumoperitoneum. It was a placebo control double blind randomized trial, conducted in Department of Anesthesia of a teaching hospital. Seventy five patients who were scheduled for laparoscopic cholecystectomy were equally divided in to three groups; placebo group (group P) received intravenous normal saline; Clonidine group (group C) received injection clonidine 2µg/kg bolus; and dexmedetomidine group (group D) received injection dexmedetomidine 1µg/kg bolus followed by continuous infusion @ 0.5µg/kg/ hour). Changes in mean blood pressure and heart rate were primarily compared. To compare quantitative variables between these groups, ANOVA test was employed, followed by Tukey’s HSD. Qualitative parameters were analyzed by chi square test. Mean arterial pressure during intubation, creation of pneumoperitoneum, desufflation and extubation was lower in group D in comparison to group C. Similarly heart rate was also lower in group D in comparison to group C during these events except during pneumoperitoneum at 45 minutes and desufflation when it was comparable in both the groups. Incidence of bradycardia and hypotension was also comparable in both the groups. Dexmedetomidine is more effective than clonidine in attenuating hemodynamic responses of intubation and pneumoperitoneum, without increasing the side effects.
Authors and Affiliations
Naveen Paliwal, Rakhi Bansal, Om Prakash Suthar, Rakesh Naval, Madhu Singhal
Keywords
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