Comparison of Dexmedetomidine, Fentanyl and Lignocaine in Attenuation of Haemodynamic Response to Direct Laryngoscopy and Intubation
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 1
Abstract
Background & Aims: Laryngoscopy and endotracheal intubation are noxious stimulus causing intense cardiovascular reflex due to sympathoadrenal discharge. The aim of this study was to compare effect of dexmedetomidine, fentanyl and lignocaine in attenuation of haemodynamic response to laryngoscopy and intubation. Methods: This hospital based, randomized, double blinded, comparative study was conducted after obtaining approval from the Institutional Ethics Committee and written informed consent from all patients. Ninety patients of ASA physical status I/II scheduled for elective surgical procedure under general anaesthesia were included in this study. These patients were randomized into three groups by chit in box method, patients in Group D received dexmedetomidine 0.6 mcg/kg diluted up to 10 ml in normal saline; in Group F received fentanyl 2 mcg/kg diluted up to 10 ml in normal saline and in Group L received 2% lignocaine 1.5 mg/kg diluted up to 10 ml in normal saline. Primary outcome variable haemodynamic response was measured at 1,3,5,7 &10 minutes after intubation. Secondary outcome variable was any adverse effects. Results:All groups were comparable with regards to demographic profile and baseline haemodynamic parameters. A statistically significant reduction (p <0.05) in heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure was observed in group D when compared to group F & group L. Conclusion: Intravenous dexmedetomidine (0.6μg/kg) showed better attenuation of haemodynamic response to laryngoscopy and intubation as compared to i.v. fentanyl (2μg/kg) and i.v. lignocaine (1.5 mg/kg 2%) when given 5 minutes prior to intubation without causing any adverse effect.
Authors and Affiliations
Dr Kanchan Chauhan, Dr Chandrashekhar Chatterji, Dr Rajeev Kumar Prajapati, Dr Anupama Gupta
Keywords
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- EP ID EP263484
- DOI 10.9790/0853-1701040106
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