Abstract

Introduction: Chronic Kidney Disease may result in abnormal turnover, coupling, and mineralization. As nephron loss causes the glomerular filtration rate (GFR) to fall below 60 ml/minute, phosphate is retained and calcium secreted inducing a rise in parathyroid hormone (PTH)that causes decrease in cortical thickness in bone and reabsorption of calcium from kidney to maintain calcium homeostasis and finally develops Renal Osteodystrophy. Material and methods: The present study was carried out at Department of Medicine, RIMS Ranchi, India during October 2016 to September 2017. Total 143 (cases and controls) subjects were selected randomly for Analytical Case Control study. All blood parameters were measured and Metacarpocortical index was calculated. Results: total 143 subjects were studied in which 71 suffered with CKD and 72 were controls. Mean Metacarpocortical index in cases was 0.387 whereas in controls group was 0.607. Metacarpocortical index was decreased by rise of serum urea, creatinine and phosphorus. Metacarpocortical index was increased by increase of serum calcium. Metacarpocortical index was deceased by deceased in eGFR. Conclusions: The study revealed that renal osteodystophy in CKD patients can be measured by simple reliable and accessible method of calculating metacarpocortical index.

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