Comparison of effectiveness among Centchroman, Danazol & Evening primrose oil for the management of mastalgia in benign breast diseases
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Introduction: Most women who present at the breast clinics have benign breast conditions which range from nonspecific breast pain to discrete lumps such as fibroadenoma. The term “benign breast diseases” encompasses a heterogeneous group of lesions including developmental abnormalities, inflammatory lesions, epithelial and stromal proliferations and neoplasm. Quantifying breast pain may be difficult because of its variability. Aims and objectivesTo estimate and compare the proportion of patient relieved from mastalgia in three groups using each drug separately.To compare the effect of three medicines in reducing the size of nodularity of benign breast diseases.To find out the extent of compliance and pattern of adverse events among three group of patients.To ascertain the cost effectiveness of therapy between the above mentioned therapeutic options.Materials and methodQuasi experimentalRandomized clinical trial undertaken on 120 patients who were clinically suspected of having mastalgia with or without nodularityand were randomized into 3 groups: Group 1Centchroman {30 mg twice weekly for 3 months},Group 2 Danazol {50 mg bid for 3 months}Group 3Evening Primrose Oil {1000mg bid for 3 months} in single surgical unit in the Department of General Surgery, BSMCH, Bankura between February, 2017 to July, 2018 ConclusionCentchroman, is a better option compared to Danazol and Evening Primrose Oil for the management of mastalgia in terms of relief of clinical manifestations, side effects and cost-effectivity.
Authors and Affiliations
Oli Das Adhikary, Dhrubajyoti Maulik, Abhijit Sarkar
Keywords
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- EP ID EP377474
- DOI 10.9790/0853-1707100105.
- Views 76
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