Comparison of Efficacy of Labetalol and Methyldopa in Patients with Pregnancy Induced Hypertension
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2014, Vol 10, Issue 3
Abstract
Despite developments in health services, maternal mortality is still very high in India. Pregnancy induced hypertension and its complications still rank amongst major cause of maternal mortality in semi urban setups like us. Antihypertensive drugs are often used to lower blood pressure and also help in reducing maternal and fetal complications. Hence, this study was planned to assess and compare efficacy of labetalol and methyldopa in controlling blood pressure in patients with pregnancy induced hypertension and study maternal and perinatal outcome in rural Indian population. Methods: 180 patients with pregnancy induced hypertension were divided into two groups randomly. After randomization, group a received methyldopa 250 mg tid and group B received labetalol 100 mg tid. Mean arterial pressure (MAP) was calculated according to formula – systolic BP+2 diastolic BP/3. Patients were subjected to 6 hourly BP monitoring. Comparison of two drugs was done daily by calculating MAP of two groups. Following observations were made as regards fall in BP with labetalol/methyldopa, time required to control BP, onset of labour spontaneous/induced, Bishop Score at induction of labour, side effects of drugs. Results: Significant fall in MAP was seen in patients receiving labetalol. Mean time required controlling BP in group A was 42.22 hrs and in group B it was 36.97 hrs. Mean Bishop Score at induction in present study in group A was 8.27 and in group B was 9.33 with a statistically significant ρ < 0.05. 33.33% patients went in spontaneous labour in group a while in group B 23 patients (48.94%) patients went in spontaneous labour. Conclusion: The freedom from maternal and fetal side effects, the efficient hypotensive action indicates that labetalol is suitable for use during pregnancy.
Authors and Affiliations
Anagha A. Jinturkar , Vrushali Khedkar , Dipti Dongaonkar
Keywords
Related Articles
- EP ID EP131526
- DOI -
- Views 106
- Downloads 0
Behavioral and Histological Observations after the Human Amniotic Epithelial Cells Transplantation in the 6-Hydroxydopamine Induced Parkinsonism Disease Model in Wistar Albino Rats
Several toxin-induced animals’ models simulate the motor deficits occurring in PD. Among them, the unilateral 6-hydroxydopamine (6-OHDA) model is frequently used in rats and has the advantage of presenting side-biased mo...
Additional role of sertraline prescribed for treatment of pre mature ejaculation in control of nightfall (nocturnal emission) - A multicenter study
In Indian culture maleness is matter of pride. The concept of maleness in India is preoccupied by various culturally reinforced false concepts. One of them is nocturnal emission induced physical weakness and sexual weakn...
A phantom study on the influence of viscosity of blood, percentage diameter stenosis, length of stenosis and cross-sectional area of blood vessel on blood flow dynamics in peripheral (brachial and femoral) artery models using Doppler ultrasound spectral analysis
Objectives: To study the influence of viscosity of blood, percentage diameter stenosis, length of stenosis and crosssectional area of blood vessel on blood flow dynamics in peripheral (brachial and femoral) artery models...
Comparative Study of Single Layer versus Double Layer Closure of Lower Transverse Uterine Incision at Cesarean Delivery
Objective(s): To assess intraoperative and postoperative outcome following single layer closure of lower transverse uterine incision at cesarean section as compared to double layer closure. Method(s): In this prospective...
Demographic profile and pattern of injuries in autopsied fatal electrocution cases in Union territory of India
Background and Objectives: This autopsy based cross-sectional study of fatal Electrocution cases in the union territory (Puducherry) are aimed to evaluate socio-demographic profile and pattern of electrical and other ass...