Comparison of fluconazole and posaconazole for fungal prophylaxis in high- risk patients with hematological malignity
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2014, Vol 4, Issue 1
Abstract
Objective:To compare the frequency of fungal infection and mortality rates in patients with hematological malignity and receiving either flucanazole (FLU) or posaconazole (POS) prophylaxis. Methods:This retrospective, observational study investigated fungal prophylaxis in patients with a high risk of invasive fungal infections (IFIs) and diagnosed with hematological malignity at our hospital hematology clinic between 01.01.2011 and 01.01.2013. FLU (n=70) was the prophylactic regimen between 2011 and 2012 which was replaced by POS (n=35) in the following period. The incidence and mortality rates of IFIs developing in the two periods were compared. Results:The incidence of IFI in patients administered FLU prophylaxis was 22/70 (31%), compared to 13/35 (37%) in the patients receiving POS. Incidence of invasive pulmonary aspergillosis (IPA) in the FLU group was 21/70 (31%), compared to 9/35 (26%) in the POS group. The mortality rate in the group receiving FLU prophylaxis was 17 (24%), compared to 4 (11%) in the POS group. The difference was attributed to causes other than fungal infection. Results of subgroup analysis performed for AML were similar to the general findings in terms of both incidences of fungal infection and of mortality levels. In multivariate analysis, mean duration of neutropenia was correlated with prophylaxis failure. Conclusion: We conclude that both agents can be successfully used in fungal infection prophylaxis for patients at high risk for IFI. J Microbiol Infect Dis 2014;4(1): 1-6 Key words: Fungal prophylaxis, invasive fungal infections, mortality
Authors and Affiliations
Selçuk Kaya, Mehmet Sönmez, İftihar Köksal, Eda Gençalioğlu, Mustafa Yılmaz, Gürdal Yılmaz
Keywords
Related Articles
- EP ID EP152172
- DOI 10.5799/ahinjs.02.2014.01.0115
- Views 134
- Downloads 0
Uygun çevre koşullarında Streptomyces albolongus ile oluşan biyoaktif metabolit üretimi
Amaç: Günümüzde konvansiyonel antibiyotiklere karşı artan direnç riski nedeniyle yeni antibiyotiklere gereksinim vardır. Bu çalışmada yeni bir antimikrobiyal bileşiğin elde edilmesi denenmektedir. Yöntemler: Bir aktino...
Emergence of Pan-drug resistance amongst gram negative bacteria! The First case series from India
Objective: Increasing prevalence of carbapenem resistant Gram negative bacteria is a serious clinical and public health challenge. Bacteria resistant to all available antibiotics (Pan Drug Resistance) herald the onset of...
Frequency of active HCV infection among anti-HCV positive patients in selected districts of Khyber Pakhtunkhwa, Pakistan
Objective: The objective of this study was to determine frequency of active HCV infection among confirmed anti-HCV positive subjects of KPK in order to help the infected subjects decide about anti-viral treatment options...
An investigation of type 3 secretion toxins encoding-genes of Pseudomonas aeruginosa isolates in a University Hospital in Egypt
Objective: Pseudomonas aeruginosa uses type 3 secretion system (T3SS) to directly inject four toxins into host cells. The aim of the study was to determine the prevalence of the toxins-encoding genes among P. aeruginosa...
Prevalence of Staphylococci in Commercially Processed Food Products in Karachi-Pakistan
Objectives: This study was designed to determine the prevalence of Staphylococci, Staphylococcus aureus (S. aureus), and Methicillin Resistant S. aureus (MRSA) in commercially prepared food items that involve human handl...