Comparison of haemodynamic response to laryngoscopy and endotracheal intubation following induction of general anaesthesia with propofol or etomidate
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 2
Abstract
Aims and Objectives Propofol and etomidate are most frequently used intravenous induction agents with very similar onset of action and duration of action few advantages over each other and few unwanted effects Recent studies and reintroduction of etomidate has paved way for its routine use in haemodynamically unstable patientsMaterials and Methods One hundred patients belonging to American Society of Anaesthesiologists ASA class I and II aged between 18 to 60 years scheduled to undergo elective surgical procedure under general anaesthesia were selected All the patients received tablet diazepam 02 mgkg as premedication and fentanyl 2 mcgkg body weight before induction Patients were be randomly allocated to group P n 50 who received propofol 2 mgkg or group E n 50 who received Etomidate 03 mgkg as induction agent for general anaesthesia Endotracheal intubation was facilitated by vecuronium 01mgkg body weight Heart rate HR Systolic blood pressure SBP diastolic blood pressure DBP and mean arterial blood pressure MAP were recorded at basal after fentanyl 1 3 5 and 10 min following inductionResults There was no significant change in the heart rate at and after the induction intubation in either group P or group E There was significant decrease in SBP DBP and MAP in group P following induction whereas there was less decrease in Group E There was increase in the SBP DBP and MAP after intubation in both the groups but in group P it did not increase above the basal and remained below the basal levels at 5 and 10 minutes following intubationConclusion Etomidate provides stable haemodynamics at induction of general anaesthesia But it does not attenuate the haemodynamic response to laryngoscopy and intubation Propofol causes significant hypotension at induction and attenuates the pressor response to laryngoscopy and intubationKeywords Propofol Etomidate Haemodynamic Laryngoscopy Blood pressure
Authors and Affiliations
Devaraj I. C. , Manjunath Timmappa Bhat, Shrirang V. Torgal
Keywords
Related Articles
- EP ID EP476451
- DOI 10.18231/2394-4994.2018.0038
- Views 73
- Downloads 0
Mechanical ventilation in trauma-the first 24 hours: A retrospective analysis
Introduction Warfare injuries are a special subset of trauma involving complex injury mechanisms and extensive tissue damage Theses mechanisms may lead to significant deterioration in lung function even in the absence of...
Comparison of epidural ropivacaine vs bupivacaine with addition of fentanyl or dexmedetomidine in major lower limb orthopaedic surgery
Background: Adequate analgesia following major lower limb orthopaedic surgeries is necessary for both intra and post-operative pain relief, to promote early ambulation and improved patient outcome. Aim: To study and comp...
A randomized controlled parallel study of nalbuphine and fentanyl on hemodynamic response to laryngoscopic and laparoscopic stress in patients undergoing laparoscopic appendectomy under general anaesthesia
Aims Hemodynamic changes caused by laryngoscopy endotrachial intubation and creation of pneumoperitonium in laparoscopic surgeries is deleterious to patients This study was done to compare nalbuphine an agonist antagonis...
Prognostic applicability of simplified acute physiology score (saps 3) in critically ill adult surgical patients in a tertiary Indian hospital: A preliminary study
Introduction and Aims: Prognostic indices are infrequently practiced in surgical intensive care units (SICU) of Indian tertiary care hospitals to assess the overall outcomes. Simplified Acute Physiology Score 3 (SAPS 3)...
A prospective randomized double blind study to compare the effects of dexmedetomidine and fentanyl on intubating conditions during awake fiberoptic bronchoscopy guided intubation
Introduction Various drugs have been used for sedation to provide adequate intubating conditions during awake fiberoptic intubation AFOI but these drugs may cause excessive sedation followed by respiratory depression whi...