Comparison of hypertonic saline versus normal saline on cytokine profile during CABG
Journal Title: DARU Journal of Pharmaceutical Sciences - Year 2012, Vol 20, Issue 0
Abstract
Background and the purpose of the study Blood contact with artificial surfaces of the extracorporeal circuit and ischemia-reperfusion injury in CABG with CPB, may lead to a systemic inflammatory response. Hypertonic saline have been recently investigated as a fluid in order to decrease inflammatory response and cytokines generation in patients undergo cardiac operations. Our purpose is to study the prophylactic effect of HS 5 % infusion versus NS on serum IL-6 as an inflammatory & IL-10 as an anti-inflammatory biomarker in CABG patients. Methods The present study is a randomized double-blinded clinical trial. 40 patients undergoing CABG were randomized to receive HS 5 % or NS before operation. Blood samples were obtained after receiving HS or NS, just before operation, 24 and 48 hours post-operatively. Plasma levels of IL-6 and IL-10 were measured by ELISA. Results and major conclusion Patients received HS had lower levels of IL-6 and higher level of IL-10 compared with NS group, however these differences were not statistically significant. Results of this study suggest that pre-treatment with small volume hypertonic saline 5 % may have beneficial effects on inflammatory response following CABG operation.
Authors and Affiliations
Mojtaba Mojtahedzadeh, Mahnaz Mazandarani, Fardin Yousefshahi, Khosro Barkhordari, Arezoo Ahmadi, Reza Shariat Moharari, Mohammad Abdollahi, Hadi Hamishehkar, Mohammad Ali Boroomand, Arash Jalaali, Mona Bashirzadeh
Keywords
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