Comparison of IL-13 and IL-27 levels between schizophrenics and healthy subjects before and after antipsychotic administration
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 9
Abstract
Many new evidences suggest cytokine activities involvement in pathogenicity of schizophrenia. Therefore, the aim of this study was to assess the serum levels of IL-13 and 27 in schizophrenics, and then compares them with those of healthy individuals. This project was conducted in 2013. First, the patients and the controls were matched based on their sex and age, then serum levels of IL-13 and 27 (ELISA) were measured at the beginning of treatment with antipsychotics, Once more, after completion of antipsychotic administration for three months, the interleukins were assayed. The results indicated that IL-13 levels in the male and female patients before treatment were significantly higher than their respective control groups (P = 0.001and P = 0.002). The amount of this cytokine three month after the treatment, showed no significant difference between the two groups (P = 0.965 and P = 0.205). The results also revealed that IL-27 levels in female patients had no significant increase before the treatment comparing to their associated control group (P = 0.625) and serum level of the cytokine in male patients was significantly low before the treatment comparing to their control subjects (p=0.009). Serum level of this cytokine demonstrated no significant difference between the patients and their control groups based on their age and sex after treating for three months (P = 0.325 and P = 0.744). The results indicated that serum levels of IL-13 and IL-27 before and after the treatment were different and treating with antipsychotics returned IL-13 and IL-27 serum levels of the patients to the same level of the controls.
Authors and Affiliations
Ali Alidadi| Assistant professor of nephrology, Nephrology Department, Zahedan University of Medical Sciences, Zahedan, Iran, Hossein Ali Khazaei| Associate Prof in Clinical immunology, Immunology and Hematology Department and Clinical Immunology Research Center of Zahedan University of Medical Sciences Zahedan-Iran, Babak Nakhjavan Shahraki| M.D sina trauma and surgery research center, tehran University of medical sciences , Tehran , Iran, Salar Andarzi| Philosophy Doctor (PhD) student in genetic ,. Department of of genetic, Faculty of Sciences, University of shahid chamran ahvaz , Iran, Arman Jalili| Philosophy Doctor (PhD) student in Sport physiology. Department of Sport Physiology of Tehran University, Tehran-Iran, Ali Mirzaei| Philosophy Doctor (PhD) in biochemistry, Yasuj University of Medical Sciences, Yasuj, Iran, Corresponding Email: mirzaee3a2003@yahoo.com, Ali Shahraki| Assistant professor of pharmacology , Department of biology, Faculty of sciences, University of Sistan and Baluchestan, Zahedan, Iran, Salah Hajinejad| Assistant professor of pharmacology , Department of biology, Faculty of sciences, University of Sistan and Baluchestan, Zahedan, Iran, Seyed Mehdi Hashemi| Hematologist and Adult Oncologist, Zahedan University of Medical Sciences, Zahedan, Iran
Keywords
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