Comparison of inhibitory effect of ibuprofen with Piper guineense Schumach and Thonn. on some reproductive hormones in female rats
Journal Title: UNKNOWN - Year 2017, Vol 6, Issue 4
Abstract
The aim of the present study was to compare the inhibitory effect of ibuprofen with oral administration of Piper guineense leaf extract on follicle-stimulating hormone, luteinizing hormone, progesterone and estrogen in female rats irrespective of the estrous cycle. The animals were randomly assigned to four groups (n = 7): group A (control), Group B, 180 mg-kg of ibuprofen, Group C, 200 mg-kg of Piper guineense extract, Group D, 180 mg-kg of ibuprofen and 200 mg-kg of Piper guineense extract. At the end of two weeks administration, rats were sacrificed under urethane anesthesia and hormones measured using enzyme-linked immunosorbent assay method. Results showed significant reduction in serum follicle-stimulating hormone and luteinizing hormone following ibuprofen administration in Group B rats at P < 0.05. Piper guineense extract treated Group C rats caused significant reduction in serum luteinizing hormone and progesterone at P < 0.05. In contrast, serum follicle stimulating hormone significantly increased in Group D rats at P < 0.05 whereas serum luteinizing hormone and progesterone were markedly reduced at P < 0.05. Serum estrogen level remained unchanged among groups. In conclusion, results obtained suggested that extract inhibited luteinization of follicles thus could impair ovulation, therefore the extract can be used as oral contraceptive in family planning.
Authors and Affiliations
Emmanuel Onuka AGBAI, Chisomaga Chiwuikem EKE, Collins Okechukwu NWANEGWO, Ugochukwu Bond ANYAEHIE
Keywords
Related Articles
- EP ID EP451444
- DOI -
- Views 67
- Downloads 0
Screening for community-acquired strains of methicillin-resistant Staphylococcus aureus susceptible to extracts of Centaurea nigrescens
The rates of infection by community-acquired multi-drug resistant Staphylococcus aureus have risen dramatically over fifteen years in the United States. Community-acquired multi-drug resistant Staphylococcus aureus is re...
Butyrylcholinsterase inhibitors from two Ficus species (Moraceae)
Alzheimer’s disease (AD) is the most common form of dementiaand mainly afflict people over 65 years of age. AD is characterized by a progressive memory loss that leads to a profound emotional disturbance in later stages....
Comparison of antiaspergillar activity of extracts of Tectona grandis Linn according to two antifungal susceptibility testing
Plants used as antimicrobials in the treatment of infectious diseases in folk medicine are regularly evaluated in different Laboratories. And, the processes of evaluation of antifungal susceptibility are often different...
Toxicity evaluation and protective effect of Rhus longipes Engl. leaf extract in paracetamol induced oxidative stress in wister rats
Aim: Acute toxicity and protective effect of ethanol leaf extract of Rhus longipes Engl. against Paracetamol induced oxidative stress was investigated. The LD50 of the leaf extract was determined using up and down techni...
GC-MS and FT-IR Profiling of leaves methanol extract from the Pleiospermium alatum (Wall. ex Wt. & Arn) Swingle Rutaceae family
The present study was aimed to analysis of bioactive constituents of leaves from the Pleiospermium alatum (Rutaceae). The methanol extract of the leaves were subjected to Fourier transform infrared spectroscopy (FTIR) an...