Comparison of intravenous ondansetron and palonosetron in prevention of postoperative nausea and vomiting in patients posted for elective laproscopic cholecystectomy
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 4
Abstract
Introduction: PONV is a major complication after anaesthesia, present in 20-30% range1 . We compared efficacy and tolerance of ondansetron and palonosetron for PONV prohylaxis in patients posted for elective laproscopic cholecystectomy. Method: 60 patients of age 20-60 years ,ASA I and II, scheduled for elective laproscopic cholecystectomy were randomized double blindly to receive either 8 mgbolus IV ondansetron and 16 mg was added to the PCA mixture (O group),or 0.075mg palonosetron only bolus dose (P group). Pregnancy, known hypersensitivity to both drugs, migraine, motion sickness were excluded. Chi squre test and Fisher exact test were used for statistic evaluation. Microsoft excel and epi info version 3.4.3 were used. P value <.05 considered significant. PONV (0 no nausea, 1 nausea,2 retching,3 vomiting), rescue antiemetics and side effects were assessed in 24 hr postoperative period. Result: Both groups were comparable in demographic parameters (age, sex, weight). Overall incidence of PONV did not differ significantly (p=.57) but patients, who needed rescue antiemetics were significantly less in group P than group O (P=<.05). Additionally side effects were also less in group P. Conclusion: In patients undergoing elective laproscopic chlecystectomy, use of palonosetron significantly reduced need of rescue antiemetics. Incidence of PONV and side effects were also less with P group
Authors and Affiliations
Dr Manoj Singhal
Keywords
Related Articles
- EP ID EP486825
- DOI -
- Views 42
- Downloads 0
Associate Professor in Physiology, JNMC Sawangi (M) Wardha, DMIMSU (DU), India
ABK is the metallic based herbal medicine, no scientific testimonial exist to conform its action and potential efficacy to proof the ancient siddhars’ quotation about Ayabirunkaraja katpam which is mentioned in reputed s...
Detection of ESBL in Pseudomonas aeruginosa from Various Clinical Specimen-A Hospital Based Study
Extended Spectrum Beta-Lactamases (ESBLs) are beta-lactamases resist against bacteria to Pencillins, Ceprhalosporins and Aztrenam (not to Cephamycins or Carbapenems) and inhibited by Beta-lactamase inhibitors such as Cla...
Ectopic Cervical Thymoma
The thymus is a lymph epithelial organ derived from the pharyngeal pouches, and anatomically located in the anterior superior mediastinum. Ectopic cervical Thymic lesions results from aberrant migration of the thymus dur...
Functional Outcome of Intervertebral Disc Prolapse Treated with Epidural Steroid and Local Anaesthetic – Prospective Study
`Disc prolapse amounts for 5% of lower back disorders. Intervertebral disc prolapse can be treated conservatively or surgically. The intervertebral disc is subject to continuous and progressive degenerative changes throu...
Profile of Adverse Drug Reactions in TB Patients Taking ATT
INTRODUCTION- Tuberculosis treatment need more than one drug combination to eradicate tuberculosis bacteria.2 The use of multidrug regimens has been associated with increased incidence of adverse drug reactions of anti-t...