COMPARISON OF INTRAVENOUS PARACETAMOL AND TRAMADOL AS PRE-EMPTIVE ANALGESIC FOR LOWER ABDOMINAL SURGERIES IN CHILDREN- A PROSPECTIVE RANDOMISED DOUBLE-BLIND STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 9
Abstract
BACKGROUND Pre-emptive analgesia is administration of an analgesic before a painful stimulus, so as to prevent central sensitisation. Intravenous (IV) formulation of paracetamol has been introduced and its safety and pharmacokinetic properties have been established for children providing excellent analgesia and avoiding side effects associated with opioids and non- steroidal antiinflammatory drugs. Present study was done to compare the analgesic effects of pre-emptive I.V. paracetamol and tramadol in children undergoing lower abdominal surgeries. MATERIALS AND METHODS Sixty-four children of ASA physical status I and II, aged 2 to 12 years scheduled for elective lower abdominal surgeries under general anaesthesia were recruited for a prospective, randomized controlled, double blinded study, into group P and group T. Following induction, group P received 15 mg/ kg I.V. paracetamol and group T 1 mg/kg tramadol in 75 ml of normal saline over 15 minutes before surgical stimulus. Postoperative modified objective pain scale (OPS), time to first rescue analgesia (FRA), Aldrete score, time to reach Aldrete score> 9, sedation scores, parent satisfaction scores and PONV were recorded for 24 hours. RESULTS Mean pain scores by OPS in group P and T were similar and statistically insignificant. Time to FRA being 320 ± 20 min in group P as compared to group T 340 ± 30 min. 12.5% patients had PONV in group P as compared to 81.5% in group T (p≤0.05). Mean duration to reach Aldrete score of 9 was 11 ± 1.5 min and 16.7 ± 3 min in group P and T respectively (p≤0.05). CONCLUSION Pre-emptive I.V. paracetamol is as efficacious as I.V. tramadol for postoperative analgesia with early recovery and lower incidence of PONV in paracetamol group.
Authors and Affiliations
Seham Syeda, Jyothi B, Pratishruti Singh, Safiya I. Shaikh
Keywords
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- EP ID EP555113
- DOI 10.14260/jemds/2019/133
- Views 76
- Downloads 0
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