COMPARISON OF LIQUISOLID AND INCLUSION COMPLEXATION TECHNIQUE FOR DISSOLUTION RATE ENHANCEMENT OF VALSARTAN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 7
Abstract
The objective of this study is to screening of suitable non volatile liquid vehicle for the formulation of liquisolid tablets such as propylene glycol, polyethylene glycol 400 and tween 80 by using mathematical equations for enhancement of dissolution rate of drug and comparison of liquisolid technique with inclusion complex of β‐cyclodextrin. Different liquisolid compacts were prepared using a mathematical model for calculating required quantities of powder and liquid ingredients to produce an acceptably flow able and compressible admixture. The prepared liquisolid systems were evaluated for their pre compression and post compression parameters. The drug-excipient interactions studies carried out by Infrared spectroscopy (IR) and X- ray diffraction (XRD). The maximum solubility of valsartan was found to be in propylene glycol. The liquisolid formulations containing propylene glycol as a non volatile solvent showed higher drug release. The IR studies confirmed that there was no interaction between the drug and excipients. The XRD analysis confirmed formation of a solid solution inside the compact matrix. All the pre compression and post compression properties of the liquisolid compacts were within the acceptable limits. Liquisolid technique can be used to improve the dissolution rate and bioavailability of low soluble drugs.
Authors and Affiliations
Hitesh Jain, T. Y. Pasha, C. S. Bais, Anil Bhandari
Keywords
Related Articles
- EP ID EP88836
- DOI 10.7897/2230-8407.0507123
- Views 105
- Downloads 0
MIDDLE EAST RESPIRATORY SYNDROME CoV: AN EVOLVING VIRAL THREAT TO HUMAN HEALTH
The Middle East respiratory syndrome (MERS) is a highly lethal respiratory disease. It is caused by a novel single-stranded, positive-sense RNA betacoronavirus (MERS-CoV). Specific drug treatment exists for MERS and infe...
PREPARATION AND EVALUATION OF MONTELUKAST ORAL DISPERSIBLE TABLETS BY DIRECT COMPRESSION METHOD
The purpose of this research was to develop oral dispersible tablets of montelukast sodium. Montelukast sodium is most commonly used in treatment of Asthma. Oral dispersible tablets were prepared by using a direct compre...
CONCEPTUAL STUDY OF THE EFFECT OF ‘UTTARBASTI’ IN ‘VANDHYATVA’ WITH SPECIAL REFERENCE TO CERVICAL FACTOR OF INFERTILITY
The most disappointing feeling for a woman is, if she could not be a mother. The present day’s life style of women is very stress full, unhealthy and unhygienic due to unawareness, hectic and fast running schedule. Vandh...
ACUTE ORAL TOXICITY OF MUCUNA PRURIENS IN SWISS ALBINO MICE
Mucuna pruriens, belonging to the botanical family Fabaceae, has been used in traditional Ayurvedic Indian medicine for various ailments including Parkinson’s disease. The current study reports the outcome of acute oral...
VIRTUAL TOXICITY STUDIES OF NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES
Virtual toxicity of N3, N5-diphenyl-1,4-dihydropyridine-3,5-dicarbohydrazides [2A-2D’] and 2,6-dimethyl-1,4-dihydropyridine-3,5-yl-bis[carbonyl-2-(phenyl)]pyrazolidine-3,5-diones] [3A-3D’] were extensively studied. Compu...