PREPARATION AND EVALUATION OF MONTELUKAST ORAL DISPERSIBLE TABLETS BY DIRECT COMPRESSION METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 7
Abstract
The purpose of this research was to develop oral dispersible tablets of montelukast sodium. Montelukast sodium is most commonly used in treatment of Asthma. Oral dispersible tablets were prepared by using a direct compression method employing superdisintegrants such as low substituted hydroxyl propyl cellulose, crospovidone, croscarmellose sodium, and sodium starch glycolate. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, in vitro disintegration time, and drug release. Other parameters such as wetting time and drug-excipient compatibility were also evaluated. The tablets' hardness was maintained in the range of 3-4 kg and friability was <1% for all formulations. All tablet formulations disintegrated rapidly in vitro within 10 to 30sec. Release of drug was faster from formulations containing 7.5% crospovidone (MF11) compared to the marketed tablets. Kinetic studies indicated that all the formulations followed first order release with diffusion mechanism. Finally, it can be reasonably expected that the obtained drug dissolution rate improvement will result in an increase of its bioavailability, with the possibility of reducing drug dosage and side effects.
Authors and Affiliations
Vijaya Kanagala , Bharat Geedi , Ravishanker Dashamukhi , Ajay Chitimalla
ORAL CANCER PREVALENCE & FINDING OF ALARMING CONSEQUENCES AT ONCOLOGY WARD OF PUBLIC HEALTH CARE SECTOR
Oral cancer is one of the most occurring cancers from 1908.Its prevalence is rapidly increasing day by day and the most commonly occurring type is squamous cell carcinoma from which more than 50,000 patients affected per...
ETHNOMEDICINAL AND PHYTOECONOMIC ELABORATION OF LILOWNAI VALLEY, DISTRICT SHANGLA, PAKISTAN
The flora of Pakistan and especially that of Northren Part has tremendous scope to evaluate their ethnomedicinal importance for more realistic way to justify their traditional usage and applications. Based on this, an et...
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF CLINDAMYCIN PHOSPHATE AND CLOTRIMAZOLE IN PHARMACEUTICAL DOSAGE FORMS
A simple, efficient and reproducible Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) method for simultaneous determination of Clindamycin phosphate and Clotrimazole in combined soft gelatin pessaries pharm...
CONTAMINATION OF MERCURY IN FISH AND ITS TOXICITY TO BOTH FISH AND HUMANS: AN OVERVIEW
Heavy metals are considered the most important form of pollution of the aquatic environment because of their toxicity and accumulation by marine organisms. The fish may be more greatly affected by anthropogenic pollution...
QUALITATIVE EVALUATION OF MARKETED AYURVEDIC RED TOOTH POWDER BY NAMBURI PHASED SPOT TEST
Simple and precise quality control analysis of consumer goods is the goal of rising FMCG sector. Ayurvedic red tooth powders are one of the most popular FMCG products in today’s market. The main ingredient (≥80%) of thes...