Comparison of Pathologic Effects of Hyaluronic Acid And Collagenase on Wound Healing of Rabbit Ear Cartilage Tissue
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Objective: We aimed to compare the effects of hyaluronic acid and collagenase on wound healing process of the rabbit ear cartilage tissue. Study Design: Experimental animal study. Methods: Eighteen New Zealand white male rabbits aged approximately 4 months and weighing from 2500 to 3000 g (mean 2800 g) were included in the experiments and randomly divided into three groups: control, hyaluronic acid and collagenase, each containing 6 rats. The wound was induced by scalpel and freer elevetor in both ears of each rabbit on which either hyaluronic acid, collagenase, or nothing(control group) was applied. Pathologic evaluations were performed 15 and 30 days after wound induction, and included the assesment of cartilage viability, inflammation, fibrosis, and glycosaminoglycan level. Results:The scores for cartilage viability, fibrosis, inflammation and glycosaminoglycan did not show significant difference between the specimens obtained at 15 days and 30 days after wound induction (p>0.05 for all). There was also no significant difference between control, hyaluronic acid and collagenase groups in terms of mean scores of cartilage viability, fibrosis, inflammation and glycosaminoglycan in 15 days and 30 days (p>0.05 for all). Conclusion: The findings of the present experimental study indicate that neither hyaluronic acid nor collagenase has any promoting effect on wound healing of ear cartilage tissue. However, further larger scale studies are needed to reach a definitive conclusion on the effect of hyaluronic acid or collagenase on wound healing process of ear cartilage tissue and to evaluate their use in clinical treatment of ear injuries.
Authors and Affiliations
Altun Hüseyin, Hanci Deniz
Keywords
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- EP ID EP380787
- DOI 10.9790/0853-1708028689.
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