Comparison of Pregabalin and Tramadol for Post-operative Pain Management in Patients Undergoing Lumbar Laminectomy
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 3
Abstract
Introduction: Prevention and treatment of post-operative pain continue to be a major challenge in post-operative care. Opioid analgesics, with their well-known side effects, continue to represent a cornerstone in post-operative pain control. Aim: Aim of this study is to assess and compare the efficacy and safety of pre-operative administration of pregabalin and tramadol in patients undergoing elective lumbar laminectomy. Materials and Methods: Group 1 was received a placebo capsule orally 1 h before anesthetic induction. Group 2 was received a tramadol capsule 100 mg orally 1 h before anesthetic induction. Group 3 was received a pregabalin capsule 150 mg 1 h before anesthetic induction. Results: The pain scores in Group 2 are less than Groups 1 and 2 preoperatively, after extubation and 1, 2, 4 and 6 h postoperatively, and this difference is significant (P < 0.05). The sedation score in Group 2 is greater than that of Group 3 which is greater than that of Group 1 preoperatively, after extubation and 1, 2, 4 and 6 h post-operatively. Fentanyl requirement is more in Group 1 compared to Group 3, which itself is more than Group 2. These differences are statistically significant. Adverse effects such as nausea, vomiting, and drowsiness are less than that of Groups 1 and 2. Conclusion: Pregabalin has a statistically significant effect when compared to placebo, but this effect is less when compared to tramadol. The need for rescue analgesia is in the least in tramadol patients followed by pregabalin, and it increases maximum in the placebo group.
Authors and Affiliations
V Manorema, R Balakrishna, Heber Anandan
Keywords
Related Articles
- EP ID EP468237
- DOI -
- Views 174
- Downloads 0
Comparative Study of Ropivacaine with Dexmedetomidine versus Ropivacaine Alone in Supraclavicular Brachial Plexus Block for Upper Limb Surgery
Background and Aims: Supraclavicular plexus block, as a regional anesthesia has taken over as principal technique for upper limb surgeries. Ropivacaine is long acting local anesthetic drug considered to produce less neur...
Spectrum of Etiology of Intestinal Obstruction - A Hospital-based Study
Introduction: Bowel obstruction remains one of the most common intra-abdominal problems of utmost complexity faced by general surgeons despite better understanding of altered physiology in disease and improved surgical t...
Pancreatic Trauma - A Management Conundrum, whether to Operate or Not to Operate and Management of Complications: A Study from a Tertiary Care Hospital in South India
Introduction: Abdominal trauma has become one of the leading causes of mortality and morbidity around the world. There is much confusion about the management of pancreatic trauma. We present our data on the management of...
Atypical Presentations of Nasopharyngeal Masses: A Case Series
Among all the tumors presenting in the head and neck region, nasopharyngeal masses shows a broad range of benign and malignant tumors, fungal infections, granulomatous inflammation, autoimmune diseases and congenital les...
A Study of Duodenal Ulcer Perforation Post-operative Outcome in A Tertiary Center
Introduction: Time trends in the epidemiology of perforated peptic ulcer disease reflect complex, multifactorial etiologies. Based on today’s fast and instant lifestyle, it is evident that the epidemiology of peptic ulce...