Comparison of Pregabalin and Tramadol for Post-operative Pain Management in Patients Undergoing Lumbar Laminectomy
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 3
Abstract
Introduction: Prevention and treatment of post-operative pain continue to be a major challenge in post-operative care. Opioid analgesics, with their well-known side effects, continue to represent a cornerstone in post-operative pain control. Aim: Aim of this study is to assess and compare the efficacy and safety of pre-operative administration of pregabalin and tramadol in patients undergoing elective lumbar laminectomy. Materials and Methods: Group 1 was received a placebo capsule orally 1 h before anesthetic induction. Group 2 was received a tramadol capsule 100 mg orally 1 h before anesthetic induction. Group 3 was received a pregabalin capsule 150 mg 1 h before anesthetic induction. Results: The pain scores in Group 2 are less than Groups 1 and 2 preoperatively, after extubation and 1, 2, 4 and 6 h postoperatively, and this difference is significant (P < 0.05). The sedation score in Group 2 is greater than that of Group 3 which is greater than that of Group 1 preoperatively, after extubation and 1, 2, 4 and 6 h post-operatively. Fentanyl requirement is more in Group 1 compared to Group 3, which itself is more than Group 2. These differences are statistically significant. Adverse effects such as nausea, vomiting, and drowsiness are less than that of Groups 1 and 2. Conclusion: Pregabalin has a statistically significant effect when compared to placebo, but this effect is less when compared to tramadol. The need for rescue analgesia is in the least in tramadol patients followed by pregabalin, and it increases maximum in the placebo group.
Authors and Affiliations
V Manorema, R Balakrishna, Heber Anandan
Keywords
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