Comparison of Propofol Alone and Propofol-Ketamine Mixture for Sedation during Endoscopic Retrograde Cholangiopancreatography (ERCP): A Randomised Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 4
Abstract
ABSTRACT Introduction: Propofol is frequently used for deep sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP). Sedation-Related Adverse Events (SRAEs), associated with propofol administration, include hypotension, arrhythmia, oxygen desaturation, unplanned intubation and procedure termination whereas, ketamine propofol combination has favourable haemodynamic effects. Aim: To evaluate the efficacy of the synergistic effect of small dose of ketamine (25 mg) and propofol in comparison with propofol alone on propofol consumption for deep sedation in patients undergoing ERCP. Materials and Methods: A total of 60 patients undergoing ERCP were randomly assigned to one of the two medication regimens through chit and box method. Patients in Group 1 (n=30) received only intravenous propofol, while patients in Group 2 (n=30) received 25 mg of i.v. ketamine along with intravenous propofol and both groups of patients were titrated to achieve deep sedation. Total propofol consumption was recorded in both groups. Results: Patients in both groups were comparable in terms of BMI, ASA status and duration of ERCP. Group 1 patients required significantly higher doses of propofol (370±123.4 mg) as compared with Group 2 (342.65±116.4 mg). The mean percentage decline in oxygen saturation during the procedure was greater in Group 1 than it was in Group 2. Conclusion: Authors concluded that during ERCP addition of ketamine to propofol resulted in decrease in propofol consumption without disturbing intra and post-procedure haemodynamic stability.
Authors and Affiliations
Aditya Garg, Mukesh Kumar Prasad, Gurdeep Singh Jheetay, Rohit Kumar Varshney, Amit Kumar Choudhary, Himani Saroha Garg
Keywords
Related Articles
- EP ID EP554846
- DOI 10.7860/JCDR/2019/40683.12768
- Views 104
- Downloads 0
Frequent Occurrence of Faulty Practices, Misconceptions and Lack of Knowledge among Hypothyroid Patients
Introduction: Hypothyroidism is a common endocrine disorder with a reported prevalence of 4%-10%. Previous studies have reported significant gaps in the basic knowledge about the condition in hypothyroid patients. It has...
Dentists’ Prescription Patterns of Non-Steroidal Anti-inflammatory Drugs and Antibiotics: A Systematic Review
ABSTRACT Introduction: Non-Steroidal Anti-inflammatory Drugs (NSAIDs) and antibiotics are the most commonly prescribed drugs by the dentists; however, the prescription patterns, as well as the inappropriate use vary amon...
Effect of Chlorhexidine and Cystatin Incorporated Adhesives on MMPs and Cysteine Cathepsin-An In-vitro Zymographic Analysis
Introduction: Host-derived proteases such as Matrix Metallo Proteinases (MMPs) and Cysteine Cathepsin have been reported to degrade the collagen matrix of incompletely-resin infiltrated dentin. In an effort to improve th...
Periodontal Conditions during Arthritis Therapy with TNF-α Blockers
ABSTRACT Introduction: Chronic Periodontitis (CP) and Rheumatoid Arthritis (RA) are both inflammatory diseases, characterised by severe inflammation of the associated tissues. Patients with RA have been reported to have...
Priapism- A Rare Presentation of Chronic Myeloid Leukaemia
Letter to Editor