Comparison of serum leptin concentration and electrolytes in pre-eclampsia and normal pregnancy
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 7, Issue 2
Abstract
Background: Preeclampsia is one of the leading causes of maternal as well as perinatal morbidity and mortality. Studies have shown that leptin has also been implicated in the pathogenesis of many of the maternal features of the disease. People with hypertension have electrolyte abnormalities when compared to normotensives. Screening pregnant women at high risk for PE with biochemical markers can reduce unnecessary suffering and health care costs by early detection and early management. Aim: To assess the level of serum leptin concentration and electrolytes in PE and normal pregnant women. Material and Methods: This study involved Group A (40 pre-eclamptic women) and Group B (40 normal pregnant).Serum Leptin was estimated by the DRG Leptin ELISA Kit and serum electrolytes concentration Na+,K+and Cl-were measured by EASYLYTE Analyser in both groups. Results: Mean serum leptin concentration was significantly higher in PE women compared to controls 28.85+7.2 ng/ml vs 24.80+6.5 ng/ml, p<0.01. The mean serum sodium level for pre-eclamptic women was found to be statistically elevated (p<0.03) than normal pregnant women.The serum levels of calcium (p<0.01) and potassium (p<0.003) in pre-eclamptic women was significantly lower than in normal pregnant women. However, chloride showed no significant changes in both groups. Conclusion: Leptin levels were significantly elevated in PE than in normal pregnant women. Serum leptin level was increased with the severity of pre-eclampsia. The results also showed significant increase in sodium level and a significant decrease in calcium and potassium levels in preeclampsia
Authors and Affiliations
S Uma Maheswari, S Sindu Priya
Keywords
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