Leptin, Insulin resistance and Dyslipidemia in Acanthosis Nigricans
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 6, Issue 1
Abstract
Background: Leptin is a adipocytokine hormone, with 167 amino acids. It acts via hypothalamic neuronal pathway, signalling satiety centre and controlling body weight. Acanthosis nigricans is associated with Leptin, obesity, metabolic syndrome, hyperinsulinemia. Methodology: 35 cases with Acanthosis nigricans and 35 controls without Acanthosis nigricans were included for the study. Height, weight, BMI, hip and waist circumference was measured. Serum was estimated for Leptin, Glucose, insulin, insulin resistance, Total cholesterol, Triglyceride, HDL, LDL, and VLDL and compared between both groups. Results and conclusion: BMI, waist/hip ratio was high compared to controls. Leptin, Glucose, insulin, insulin resistance, Total cholesterol, LDL was increased in cases compared to controls. Triglyceride, HDL and VLDL didn’t show significant changes. Hyperleptinemia, hyperglycemia, hyperinsulinemia, insulin resistance and dyslipidemia is associated with Acanthosis nigricans.
Authors and Affiliations
Shantha kumari N, Nataraj B, Karthik G
Keywords
Related Articles
- EP ID EP359258
- DOI -
- Views 164
- Downloads 0
A study of Liver function and Renal function tests in chronic alcoholics at a tertiary health care centre
Background: More than 3 million people died as a result of harmful use of alcohol in 2016, according a report released by the World Health Organization (WHO). This represents 1 in 20 deaths. More than three quarters of t...
A study of correlation of HbA1c and homocysteine level in type II diabetic patients at tertiary health care centre
Background: Diabetes mellitus (DM) is a group disorder characterized by hyperglycemia resulting from defects in insulin secretion or insulin action. Aims and Objectives: To Study correlation of HbA1C and homocysteine lev...
Creatinine estimation by compensated Jaffe method and enzymatic method - A comparative study
Background: Chronic Kidney Disease is a global threat to health particularly for developing countries, since therapy is expensive and life-long. Incidence of CKD has doubled in the last 15 years. Accurate creatinine meas...
Role of 25 hydroxy Vitamin-D in parkinson’s disease
Abstract Problem statement: Parkinson disease is the second most prevalent neurodegenerative disease worldwide. In the initial stage of the disease, the most obvious symptoms are movement related, which include tremors,...
Serum lipid profile and Psoriasis – A case control study
Background: Psoriasis is a chronic inflammatory skin disease characterized by excessive cellular replication. It is associated with an atherogenic lipid profile. The prevalence of cardiovascular disorders in these patien...