Leptin, Insulin resistance and Dyslipidemia in Acanthosis Nigricans
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 6, Issue 1
Abstract
Background: Leptin is a adipocytokine hormone, with 167 amino acids. It acts via hypothalamic neuronal pathway, signalling satiety centre and controlling body weight. Acanthosis nigricans is associated with Leptin, obesity, metabolic syndrome, hyperinsulinemia. Methodology: 35 cases with Acanthosis nigricans and 35 controls without Acanthosis nigricans were included for the study. Height, weight, BMI, hip and waist circumference was measured. Serum was estimated for Leptin, Glucose, insulin, insulin resistance, Total cholesterol, Triglyceride, HDL, LDL, and VLDL and compared between both groups. Results and conclusion: BMI, waist/hip ratio was high compared to controls. Leptin, Glucose, insulin, insulin resistance, Total cholesterol, LDL was increased in cases compared to controls. Triglyceride, HDL and VLDL didn’t show significant changes. Hyperleptinemia, hyperglycemia, hyperinsulinemia, insulin resistance and dyslipidemia is associated with Acanthosis nigricans.
Authors and Affiliations
Shantha kumari N, Nataraj B, Karthik G
Keywords
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